Longitudinal associations between amygdala reactivity and cannabis use in a large sample of adolescents.
Rationale: The amygdala is a key brain structure to study in relation to cannabis use as reflected by its high-density of cannabinoid receptors and functional reactivity to processes relevant to drug use. Previously, we identified a correlation between cannabis use in early adolescence and amygdala...
| Publicado en: | Psychopharmacology Vol. 237; no. 11; pp. 3447 - 3459 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146477656&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146477656 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Nov2020 vid: 237 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 146477656 145020098 10.1007/s00213-020-05624-7 146477656 ppf: 3447 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Longitudinal associations between amygdala reactivity and cannabis use in a large sample of adolescents. aug: au: Spechler, Philip A. Chaarani, Bader Orr, Catherine Albaugh, Matthew D. Fontaine, Nicholas R. Higgins, Stephen T. Banaschewski, Tobias Bokde, Arun L. W. Quinlan, Erin Burke Desrivières, Sylvane Flor, Herta Grigis, Antoine Gowland, Penny Heinz, Andreas Ittermann, Bernd Artiges, Eric Martinot, Marie-Laure Paillère Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš affil: Vermont Center on Behavior and Health, University of Vermont, 05401, Burlington, VT, USA sug: ab: Rationale: The amygdala is a key brain structure to study in relation to cannabis use as reflected by its high-density of cannabinoid receptors and functional reactivity to processes relevant to drug use. Previously, we identified a correlation between cannabis use in early adolescence and amygdala hyper-reactivity to angry faces (Spechler et al. 2015). Objectives: Here, we leveraged the longitudinal aspect of the same dataset (the IMAGEN study) to determine (1) if amygdala hyper-reactivity predicts future cannabis use and (2) if amygdala reactivity is affected by prolonged cannabis exposure during adolescence. Methods: First, linear regressions predicted the level of cannabis use by age 19 using amygdala reactivity to angry faces measured at age 14 prior to cannabis exposure in a sample of 1119 participants. Next, we evaluated the time course of amygdala functional development from age 14 to 19 for angry face processing and how it might be associated with protracted cannabis use throughout this developmental window. We compared the sample from Spechler et al. 2015, the majority of whom escalated their use over the 5-year interval, to a matched sample of non-users. Results: Right amygdala reactivity to angry faces significantly predicted cannabis use 5 years later in a dose-response fashion. Cannabis-naïve adolescents demonstrated the lowest levels of amygdala reactivity. No such predictive relationship was identified for alcohol or cigarette use. Next, follow-up analyses indicated a significant group-by-time interaction for the right amygdala. Conclusions: (1) Right amygdala hyper-reactivity is predictive of future cannabis use, and (2) protracted cannabis exposure during adolescence may alter the rate of neurotypical functional development. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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