Structural MRI and tract-based spatial statistical analysis of diffusion tensor imaging in children with hemimegalencephaly.
Purpose: To investigate the gross white matter abnormalities in the structural brain MR imaging as well as white matter microstructural alterations using tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) in both affected and contralateral cerebral hemispheres of childr...
| Published in: | Neuroradiology Vol. 62; no. 11; pp. 1467 - 1475 |
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| Main Authors: | , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Nov2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146495144&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146495144 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Nov2020 vid: 62 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 146495144 145213785 146495144 146495144 10.1007/s00234-020-02491-z 146495144 ppf: 1467 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Structural MRI and tract-based spatial statistical analysis of diffusion tensor imaging in children with hemimegalencephaly. aug: au: Jeon, Tae Yeon Poliakov, Andrew V. Friedman, Seth D. Bozarth, Xiuhua L. Novotny, Edward J. Hauptman, Jason S. Moon, Sung-Hoon Shaw, Dennis W. W. affil: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, Republic of Korea sug: subj: Magnetic Resonance Imaging Methods Malformations of Cortical Development White Matter Abnormalities Human Brain Physiopathology Retrospective Design Male Female Infant Child, Preschool Child Adolescence Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Male Female ab: Purpose: To investigate the gross white matter abnormalities in the structural brain MR imaging as well as white matter microstructural alterations using tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) in both affected and contralateral cerebral hemispheres of children with hemimegalencephaly (HMEG). Methods: From 2003 to 2019, we retrospectively reviewed brain MR images in 20 children (11 boys, 2 days–16.5 years) with HMEG, focusing on gross white matter abnormalities. DTI was evaluated in 12 patients (8 boys, 3 months–16.5 years) with HMEG and 12 age-, sex-, and magnetic field strength-matched control subjects. TBSS analysis was performed to analyze main white matter tracts. Regions of significant differences in fractional anisotropy (FA) were determined between HMEG and control subjects and between affected and contralateral hemispheres of HMEG. Results: Gross white matter abnormalities were noted in both affected (n = 20, 100%) and contralateral hemisphere (n = 4, 20%) of HMEG. FA values were significantly decreased in both hemispheres of HMEG, compared with control subjects (P < 0.05). Contralateral hemispheres of HMEG showed regions with significantly decreased FA values compared with affected hemispheres (P < 0.05). Conclusions: In addition to gross white matter abnormalities particularly evident in affected hemispheres, DTI analysis detected widespread microstructural alterations in both affected and contralateral hemispheres in HMEG suggesting HMEG may involve broader abnormalities in neuronal networks. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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