Collagen-targeted molecular imaging in diffuse liver diseases.
Liver fibrosis is a common pathway shared by all progressive chronic liver diseases (CLD) regardless of the underlying etiologies. With liver biopsy being the gold standard in assessing fibrosis degree, there is a large unmet clinical need to develop non-invasive imaging tools that can directly and...
| Publicado en: | Abdominal Radiology Vol. 45; no. 11; pp. 3545 - 3557 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146680829&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146680829 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Nov2020 vid: 45 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 146680829 144865289 10.1007/s00261-020-02677-2 146680829 ppf: 3545 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Collagen-targeted molecular imaging in diffuse liver diseases. aug: au: Zhou, Iris Y. Tanabe, Kenneth K. Fuchs, Bryan C. Caravan, Peter affil: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA sug: ab: Liver fibrosis is a common pathway shared by all progressive chronic liver diseases (CLD) regardless of the underlying etiologies. With liver biopsy being the gold standard in assessing fibrosis degree, there is a large unmet clinical need to develop non-invasive imaging tools that can directly and repeatedly quantify fibrosis throughout the liver for a more accurate assessment of disease burden, progression, and treatment response. Type I collagen is a particularly attractive target for molecular imaging as its excessive deposition is specific to fibrosis, and it is present in concentrations suitable for many imaging modalities. Novel molecular MRI contrast agents designed to bind with collagen provide direct quantification of collagen deposition, which have been validated across animal species and liver injury models. Collagen-targeted molecular imaging probes hold great promise not only as a tool for initial staging and surveillance of fibrosis progression, but also as a marker of fibrosis regression in drug trials. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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