Association between Circulating Growth Differentiation Factor 15 and Cirrhotic Primary Biliary Cholangitis.
Primary biliary cholangitis (PBC) is a common condition that usually shows a progressive course towards cirrhosis without adequate treatment. Growth differentiation factor 15 (GDF15) plays multiple roles in various pathological conditions. The overall role of circulating GDF15 in cirrhotic PBC requi...
| Publicado en: | BioMed Research International pp. 1 - 12 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
10/29/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146704755&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146704755 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 10/29/2020 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 146704755 146704755 146704755 10.1155/2020/5162541 146704755 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between Circulating Growth Differentiation Factor 15 and Cirrhotic Primary Biliary Cholangitis. aug: au: Li, Zhanyi Liu, Yu Li, Xiangyong Wu, Yuankai Yang, Fangji Mo, Qiwan Chong, Yutian affil: Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China sug: subj: Cholangitis Physiopathology Liver Cirrhosis Physiopathology Cytokines Blood Cholangitis Prognosis Liver Cirrhosis Prognosis Biological Markers Blood Growth Differentiation Factors Human Immunoenzyme Techniques Body Weight Changes Albumins Blood Bilirubin Blood Bile Acids and Salts Blood Descriptive Statistics C-Reactive Protein Blood ROC Curve Liver Cirrhosis Diagnosis Sensitivity and Specificity Severity of Illness Indices Biochemical Phenomena ab: Primary biliary cholangitis (PBC) is a common condition that usually shows a progressive course towards cirrhosis without adequate treatment. Growth differentiation factor 15 (GDF15) plays multiple roles in various pathological conditions. The overall role of circulating GDF15 in cirrhotic PBC requires further investigation. Twenty patients with cirrhotic PBC, 26 with non-cirrhotic PBC, and 10 healthy subjects were enrolled between 2014 and 2018, and the serum levels of GDF15 were measured via enzyme immunoassay. The correlations between serum GDF15, weight, biochemical parameters, and the prognosis were analysed. Serum levels of GDF15 were significantly higher in cirrhotic PBC patients than in non-cirrhotic PBC patients or healthy controls (p = 0.009 and p < 0.001 , respectively). The circulating GDF15 levels strongly correlated with weight changes (r = − 0.541 , p = 0.0138), albumin (r = − 0.775 , p < 0.0001), direct bilirubin (r = − 0.786 , p < 0.0001), total bile acids (r = 0.585 , p = 0.007), and C-reactive protein (r = 0.718 , p = 0.0005). Moreover, circulating GDF15 levels strongly correlated with the Mayo risk score (r = 0.685 , p = 0.0009) and Model for End-stage Liver Disease score (r = 0.687 , p = 0.0008). Determined by the area under the receiver operating characteristic curves, the overall diagnostic accuracies of GDF15 were as follows: cirrhosis = 0.725 (>3646.55 pg/mL, sensitivity: 70.0%, specificity: 69.2%), decompensated cirrhosis = 0.956 (>4073.30 pg/mL, sensitivity: 84.62%, specificity: 100%), and cirrhotic biochemical non-responders = 0.835 (>3479.20 pg/mL, sensitivity: 71.43%, specificity: 92.31%). GDF15 may be a useful and integrated biochemical marker to evaluate not only the disease severity and prognosis but also the nutrition and response to treatment of cirrhotic PBC patients, and its overall performance is satisfactory. Therapy targeting GDF15 is likely to benefit cirrhotic PBC patients and is worth further research. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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