circ2GO: A Database Linking Circular RNAs to Gene Function.
Simple Summary: Ribonucleic acids (RNAs) are generally linear chains of nucleotides which function in many cellular processes, best known in protein biosynthesis. In the last decade, circular RNAs have been discovered which are circularized after their synthesis and differ in important features from...
| Publicado en: | Cancers Vol. 12; no. 10; pp. 2975 - 2976 |
|---|---|
| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
MDPI
Oct2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146748751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146748751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726694 B74B jtl: Cancers issn: 20726694 maglogo: N pubinfo: dt: Oct2020 vid: 12 iid: 10 pid: 97109 pub: MDPI artinfo: ui: 146748751 146748751 146748751 10.3390/cancers12102975 146748751 ppf: 2975 ppct: 1 formats: tig: atl: circ2GO: A Database Linking Circular RNAs to Gene Function. aug: au: Lyu, Yanhong Caudron-Herger, Maiwen Diederichs, Sven affil: Department of Thoracic Surgery, Division of Cancer Research, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany sug: subj: RNA, Circular Physiology Database Design Cell Line, Tumor Lung Neoplasms Genes Ontologies MicroRNA Human ab: Simple Summary: Ribonucleic acids (RNAs) are generally linear chains of nucleotides which function in many cellular processes, best known in protein biosynthesis. In the last decade, circular RNAs have been discovered which are circularized after their synthesis and differ in important features from linear RNAs. These circular RNAs have meanwhile been implicated in important cellular processes in health and disease. Here, we present a comprehensive database, circ2GO, compiling and analyzing circular RNAs found in lung cancer cell lines providing the data in tables as well as visualizing it in transcript maps and in heatmaps. Importantly, we also provide easy-to-use online tools to find circular forms of genes associated with specific molecular functions, biological processes or cellular components or predict their targeted microRNAs. This resource will enable researchers to rapidly identify circular RNAs relevant for their specific research question. Circular RNAs (circRNAs) play critical roles in a broad spectrum of physiological and pathological processes, including cancer. Here, we provide a comprehensive database—circ2GO—systematically linking circRNAs to the functions and processes of their linear counterparts. circ2GO contains 148,811 circular human RNAs originating from 12,251 genes, which we derived from deep transcriptomics after rRNA depletion in a panel of 60 lung cancer and non-transformed cell lines. The broad circRNA expression dataset is mapped to all isoforms of the respective gene. The data are visualized in transcript maps and in heatmaps, to intuitively display a comprehensive portrait for the abundance of circRNAs across transcripts and cell lines. By integrating gene ontology (GO) information for all genes in our dataset, circ2GO builds a connection between circRNAs and their host genes' biological functions and molecular mechanisms. Additionally, circ2GO offers target predictions for circRNA—microRNA (miRNA) pairs for 25,166 highly abundant circRNAs from 6578 genes and 897 high-confidence human miRNAs. Visualization, user-friendliness, intuitive and advanced forward and reverse search options, batch processing and download options make circ2GO a comprehensive source for circRNA information to build hypotheses on their function, processes, and miRNA targets. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|