Apomorphine for the Treatment of Erectile Dysfunction: Systematic Review and Meta-Analysis.
Sublingual apomorphine could be an option in patients with erectile dysfunction who cannot take phosphodiesterase type 5 inhibitors (e.g., using nitrates). We have completed a systematic review to evaluate the effects of sublingual apomorphine comparing with placebo for treating erectile dysfunction...
| Publicado en: | Archives of Sexual Behavior Vol. 49; no. 8; pp. 2963 - 2980 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
Springer Nature
Nov2020
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=146832873&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 146832873 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00040002 ASX jtl: Archives of Sexual Behavior issn: 00040002 maglogo: N pubinfo: dt: Nov2020 vid: 49 iid: 8 pid: 237 pub: Springer Nature artinfo: ui: 146832873 10.1007/s10508-020-01817-5 ppf: 2963 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P size: 727KB tig: atl: Apomorphine for the Treatment of Erectile Dysfunction: Systematic Review and Meta-Analysis. aug: au: Guillén, Virginia Rueda, José-Ramón Lopez-Argumedo, Marta Solà, Ivan Ballesteros, Javier affil: Department of Neuroscience, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, Spain Department of Preventive Medicine and Public Health, Faculty of Medicine and Nursing, University of the Basque Country, 48080, Leioa, Spain Department of Health, Osteba, Basque Office for Health Technology Assessment, Vitoria-Gasteiz, Spain Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau, CIBER Epidemiología y Salud Pública, Universitat Autònoma de Barcelona, Barcelona, Spain CIBER Salud Mental, Madrid, Spain su: Sexual intercourse Placebos Randomized controlled trials Apomorphine Impotence Meta-analysis sug: subj: Sexual intercourse Placebos Randomized controlled trials Apomorphine Impotence Meta-analysis keyword: DSM-5 Erectile dysfunction Randomized controlled trial (RCT) DSM-5 Erectile dysfunction Randomized controlled trial (RCT) ab: Sublingual apomorphine could be an option in patients with erectile dysfunction who cannot take phosphodiesterase type 5 inhibitors (e.g., using nitrates). We have completed a systematic review to evaluate the effects of sublingual apomorphine comparing with placebo for treating erectile dysfunction. The evidence searching process finished on 9 January 2019. We included nine randomized controlled trials (RCTs). Treatment length varied from 4 to 8 weeks and doses ranged from 2 to 6 mg. The percent of successful sexual intercourse attempts per ingested dose of apomorphine was evaluated in eight studies. All the studies found that apomorphine was better than placebo (6–27% more successful intercourse attempts than with placebo), but differences were not statistically significant in one study done in patients previously treated with radical prostatectomy. Regarding erectile function scores, three studies reported higher improvement on the erectile function scores for apomorphine. Differences with placebo were not clinically relevant in another two studies, one in which only diabetic patients were included and one in which only patients with radical prostatectomy were involved. Discontinuation of treatment due to adverse events was higher for apomorphine, particularly for higher doses. Available evidence suggests that sublingual apomorphine is more effective than placebo, except for patients previously treated with radical prostatectomy, and is generally well tolerated at doses of 2 or 3 mg. Nowadays, sublingual apomorphine is the only licensed oral drug for erectile dysfunction not absolutely contraindicated with nitrates use, and more RCTs should be performed to evaluate its effects and safety for treating ED. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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