Frequency-dependent changes in fractional amplitude of low-frequency oscillations in Alzheimer's disease: a resting-state fMRI study.
Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly individuals. We conducted this study to examine whether alterations in the fractional amplitudes of low-frequency fluctuations (fALFF) in the AD spectrum were frequency-dependent and symptom-relevant. A total of 43 pati...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 6; pp. 2187 - 2202 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146869367&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146869367 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2020 vid: 14 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 146869367 146869367 NLM31478145 146869367 10.1007/s11682-019-00169-6 NLM31478145 146869367 ppf: 2187 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Frequency-dependent changes in fractional amplitude of low-frequency oscillations in Alzheimer's disease: a resting-state fMRI study. aug: au: Yang, Liu Yan, Yan Li, Yuxia Hu, Xiaochen Lu, Jie Chan, Piu Yan, Tianyi Han, Ying affil: Department of Neurology, Xuanwu Hospital of Capital Medical University, No.45 Street Changchun, District Xichen, 100053, Beijing, China sug: subj: Alzheimer's Disease Pathology Alzheimer's Disease Magnetic Resonance Imaging Aged Brain Mapping Brain Pathology Brain Human Funding Source Aged: 65+ years ab: Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly individuals. We conducted this study to examine whether alterations in the fractional amplitudes of low-frequency fluctuations (fALFF) in the AD spectrum were frequency-dependent and symptom-relevant. A total of 43 patients with subjective cognitive decline (SCD), 52 with amnestic mild cognitive impairment (aMCI), 44 with Alzheimer's dementia (d-AD) and 55 well-matched controls participated in resting-state functional magnetic resonance imaging (rs-fMRI) scans. The amplitudes were measured using fALFF within the slow-4 (0.027-0.073 Hz) and slow-5 (0.01-0.027 Hz) bands. Repeated-measures analysis of variance was performed on fALFF within two bands and correlated with neuropsychological test scores. The significant main effects of frequency and group on fALFF differed widely across brain regions. There were more varied areas in the slow-5 band than the slow-4 band. The fALFF associated with primary disease effects was mainly distributed in the parietal lobe. Obvious frequency band and group interaction effects were observed in the left angular gyrus, left calcarine fissure and surrounding cortex, left superior cerebellum, left cuneus and right lingual gyrus. Neuropsychological tests scores were significantly correlated with the fALFF magnitude of the left cuneus and right lingual in the slow-5 band. Our results suggested that the AD continuum had abnormal amplitudes in intrinsic brain activity, and these abnormalities were frequency-dependent and mainly associated with the slow-5 band rather than the slow-4 band. This may guide the frequency choice of future rs-fMRI studies and provide new insights into the neuropathophysiology of AD. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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