Voxel-based morphometry results in first-episode schizophrenia: a comparison of publicly available software packages.
Investigations of brain structure in schizophrenia using magnetic resonance imaging (MRI) have identified variations in regional grey matter (GM) volume throughout the brain but the results are mixed. This study aims to investigate whether the inconsistent voxel-based morphometry (VBM) findings in s...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 6; pp. 2224 - 2232 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146869370&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146869370 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2020 vid: 14 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 146869370 146869370 NLM31377989 146869370 10.1007/s11682-019-00172-x NLM31377989 146869370 ppf: 2224 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Voxel-based morphometry results in first-episode schizophrenia: a comparison of publicly available software packages. aug: au: Li, Chen Liu, Wenming Guo, Fan Wang, Xingrui Kang, Xiaowei Xu, Yongqiang Xi, Yibin Wang, Huaning Zhu, Yuanqiang Yin, Hong affil: Department of Radiology, Xijing Hospital, Fourth Military Medical University, No. 127 West Changle Road, 710032, Xi'an, China sug: subj: Schizophrenia Software Gray Matter Magnetic Resonance Imaging Cerebral Cortex Image Processing, Computer Assisted Brain Human Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales ab: Investigations of brain structure in schizophrenia using magnetic resonance imaging (MRI) have identified variations in regional grey matter (GM) volume throughout the brain but the results are mixed. This study aims to investigate whether the inconsistent voxel-based morphometry (VBM) findings in schizophrenia are due to the use of different software packages. T1 MRI images were obtained from 86 first-episode schizophrenia (FESZ) patients and 86 age- and gender-matched Healthy controls (HCs). VBM analysis was carried out using FMRIB software library (FSL) 5.0 and statistical parametric mapping 8 (SPM8). All images were processed using the default parameter settings as provided by these software packages. FSL-VBM revealed widespread GM volume reductions in FESZ patients compared with HCs, however, for SPM-VBM, only increased and circumscribed GM volume changes were found, both software revealed increased GM volume within cerebellum. Significant correlations between Positive and Negative Syndrome Scale (PANSS) and GM volume were mainly found in frontal regions. Algorithms of GM tissue segmentation, image registration and statistical strategies might contribute to these disparate results. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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