Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study.
As a relay center between the cerebral cortex and various subcortical brain areas, the thalamus is repeatedly associated with the dysfunction of brain-gut interaction in patients with irritable bowel syndrome (IBS). However, the regional morphological alterations of the thalamus in IBS are not well...
| Published in: | Brain Imaging & Behavior Vol. 14; no. 6; pp. 2302 - 2311 |
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| Main Authors: | , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Dec2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146869377&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146869377 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2020 vid: 14 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 146869377 146869377 NLM31468373 146869377 10.1007/s11682-019-00181-w NLM31468373 146869377 ppf: 2302 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study. aug: au: Mao, Cui Ping Chen, Fen Rong Sun, Hong Hong Shi, Mei Juan Yang, Hua Juan Li, Xiao Hui Ding, Dun affil: Department of Medical Imaging, Second Affiliated Hospital of Xi'an Jiaotong University, 157, Xiwu Road, 710004, Xi'an, Shaanxi, People's Republic of China sug: subj: Thalamus Diarrhea Irritable Bowel Syndrome Pathology Thalamus Pathology Diarrhea Pathology Irritable Bowel Syndrome Magnetic Resonance Imaging Cross Sectional Studies Funding Source Human ab: As a relay center between the cerebral cortex and various subcortical brain areas, the thalamus is repeatedly associated with the dysfunction of brain-gut interaction in patients with irritable bowel syndrome (IBS). However, the regional morphological alterations of the thalamus in IBS are not well defined. We acquired structural magnetic resonance data from 34 patients with IBS and 34 demographically similar healthy subjects. Data processing was performed using FMRIB's Integrated Registration and Segmentation Tool (FIRST). Volumetric analysis and surface-based vertex analysis were both carried out to characterize the morphology of the thalamus and other subcortical structures. Our results suggested that the majority (31 cases) of the patients with IBS had diarrhea-predominant symptoms. Volumetric analysis revealed a larger normalized volume of the right thalamus and left caudate nucleus in patients with IBS than in healthy controls. Surface analysis indicated that the difference arose mainly from the laterodorsal nucleus of the right thalamus, and the body of the left caudate nucleus. In addition, patients with IBS had different hemispheric asymmetries of the thalamus (rightward) and caudate nucleus (leftward) from controls (leftward for the thalamus and rightward for the caudate nucleus). In general, our results indicated that patients with diarrhea-predominant IBS had enlarged thalamus and caudate nucleus volumes, as well as altered hemispheric asymmetries of these two structures, compared with healthy controls. The neuroimaging evidence of these structural alterations helps clarify the underlying pathophysiology of diarrhea-predominant IBS. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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