Topological changes in white matter connectivity network in patients with Parkinson's disease and depression.
Depression is the most common non-motor symptom accompanying Parkinson's disease (PD) with high prevalence but unclear pathophysiological mechanism. Relatively little is known about the topological patterns of white matter structural networks in depressed patients with PD. In this study, we used dif...
| Publicado en: | Brain Imaging & Behavior Vol. 14; no. 6; pp. 2559 - 2569 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146869399&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146869399 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2020 vid: 14 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 146869399 146869399 NLM31909443 146869399 10.1007/s11682-019-00208-2 NLM31909443 146869399 ppf: 2559 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Topological changes in white matter connectivity network in patients with Parkinson's disease and depression. aug: au: Hu, Xiao Qian, Long Zhang, Yaoyu Xu, Yuanyuan Zheng, Li Liu, Yijun Zhang, Xiangrong Zhang, Yi Liu, Weiguo affil: Department of Radiology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, 210029, Nanjing, China sug: subj: Brain Parkinson Disease Magnetic Resonance Imaging Brain Mapping Depression Human Funding Source ab: Depression is the most common non-motor symptom accompanying Parkinson's disease (PD) with high prevalence but unclear pathophysiological mechanism. Relatively little is known about the topological patterns of white matter structural networks in depressed patients with PD. In this study, we used diffusion-tensor imaging (DTI) and graph theory approaches to explore the brain structural connectome in non-depressed patients with PD (n = 47), depressed patients with PD (n = 20) and healthy controls (n = 46). All three groups exhibited small-world topology. Compared with healthy controls, non-depressed patients with PD and depressed patients with PD showed a significant reduction of network efficiency in the cortico-subcortical circuits. Moreover, depressed patients with PD exhibited higher network efficiency in fronto-limbic system, compared to non-depressed patients with PD. To sum up, our data indicated a disrupted integrity in the large-scale brain systems in depressed patients with PD patients. The structural connectome provided a basis for functional alterations in depressed patients with PD that may advance our current understanding of pathophysiological mechanism underlying Parkinson's disease. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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