Thyroid Hormone Signalling Alteration in Diabetic Nephropathy and Cardiomyopathy: a "Switch" to the Foetal Gene Programme.
Purpose Of the Review: In this study, we will analyse how diabetes induces the reactivation of organs' developmental programmes and growth, discuss how thyroid hormone (TH) signalling orchestrates these processes, and suggest novel strategies for exploiting TH-mediated reparative and regenerative pr...
| Publicado en: | Current Diabetes Reports Vol. 20; no. 11; pp. 1 - 8 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Nov2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146893540&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146893540 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15344827 3H8T jtl: Current Diabetes Reports issn: 15344827 maglogo: N pubinfo: dt: Nov2020 vid: 20 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 146893540 146893540 NLM32984910 146893540 10.1007/s11892-020-01344-6 NLM32984910 146893540 ppf: 1 ppct: 7 formats: tig: atl: Thyroid Hormone Signalling Alteration in Diabetic Nephropathy and Cardiomyopathy: a "Switch" to the Foetal Gene Programme. aug: au: Mantzouratou, Polyxeni Lavecchia, Angelo Michele Novelli, Rubina Xinaris, Christodoulos affil: Department of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Via Stezzano 87, 24126, Bergamo, Italy sug: subj: Myocardial Diseases Diabetic Nephropathies Diabetes Mellitus Human Thyroid Hormones Receptors, Cell Surface Metabolism Signal Transduction Clinical Assessment Tools Scales ab: Purpose Of the Review: In this study, we will analyse how diabetes induces the reactivation of organs' developmental programmes and growth, discuss how thyroid hormone (TH) signalling orchestrates these processes, and suggest novel strategies for exploiting TH-mediated reparative and regenerative properties.Recent Findings: Diabetes is a global pandemic that poses an enormous threat to human health. The kidney and the heart are among the organs that are the most severely damaged by diabetes over time. They undergo profound metabolic, structural, and functional changes that may be due (at least partially) to a recapitulation of their early developmental programmes. There is growing evidence to suggest that this foetal reprogramming is controlled by the TH/TH receptor alpha 1 (TRα1) axis. We introduce the hypothesis that in diabetes-and probably in other diseases-TH signalling acts in an antagonistic manner: it recapitulates a foetal profile that is necessary to coordinate metabolic and structural adaptations to sustain energy preservation and growth, but in the long term the persistent changes in these pathways are detrimental. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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