Efficacy of alginate‐and chitosan‐based scaffolds on the healing of diabetic skin wounds in animal experimental models and cell studies: A systematic review.
This systematic literature review was aimed to investigate the use of cell culture and animal models to evaluate the efficacy of alginate‐and chitosan‐based scaffolds on diabetic wound healing. We electronically searched the articles published until July 2019. The databases included five English dat...
| Publicado en: | Wound Repair & Regeneration Vol. 28; no. 6; pp. 751 - 772 |
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| Autores principales: | , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Nov2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146915413&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146915413 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Nov2020 vid: 28 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 146915413 145896587 146915413 146915413 10.1111/wrr.12857 146915413 ppf: 751 ppct: 21 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Efficacy of alginate‐and chitosan‐based scaffolds on the healing of diabetic skin wounds in animal experimental models and cell studies: A systematic review. aug: au: Cai, Hong Li, Guichen affil: Center for Cognition and Brain Sciences, University of Macau, Macao, China sug: subj: Diabetic Foot Drug Therapy Wounds and Injuries Alginates Pharmacodynamics Tissue Scaffolds Wound Healing Cell Line Drug Effects Models, Biological Cell Culture Techniques Animal Studies Systematic Review PubMed Embase Cochrane Library CINAHL Database Drug Therapy, Combination Treatment Outcomes Evaluation ab: This systematic literature review was aimed to investigate the use of cell culture and animal models to evaluate the efficacy of alginate‐and chitosan‐based scaffolds on diabetic wound healing. We electronically searched the articles published until July 2019. The databases included five English databases such as PubMed, Web of Science, Embase, the Cochrane Library, CINAHL, and three Chinese databases like CNKI, WanFang Data, and VIP. The related articles were manually searched to identify studies that were not searched by electronic database searches. Twenty‐nine studies met the inclusion criteria. We divided the results into three groups: chitosan, alginate, and a combination of chitosan and alginate. Chitosan‐, alginate‐, and a combination of chitosan and alginate‐based scaffolds showed good intervention effects on wound healing. Chitosan‐based scaffolds were effective in diabetic skin wound healing. The effects of alginate and the combination of chitosan‐and alginate‐based scaffolds on diabetic skin wounds still need more research. However, due to the heterogeneity of animal and cell preclinical trials and the validity of the statistical analysis used in these studies, it is necessary to conduct a thorough study using well‐designed experiments to confirm these results. In addition, properly designed chitosan‐and/or alginate‐based scaffolds with thorough preclinical evaluations are required prior to clinical applications. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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