Coronary vessel formation in development and disease: mechanisms and insights for therapy.
The formation of new blood vessels after myocardial infarction (MI) is essential for the survival of existing and regenerated cardiac tissue. However, the extent of endogenous revascularization after MI is insufficient, and MI can often result in ventricular remodelling, progression to heart failure...
| Publicado en: | Nature Reviews Cardiology Vol. 17; no. 12; pp. 790 - 807 |
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| Autores principales: | , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=146931501&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 146931501 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17595002 8UU1 jtl: Nature Reviews Cardiology issn: 17595002 maglogo: N pubinfo: dt: Dec2020 vid: 17 iid: 12 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 146931501 146931501 NLM32587347 146931501 10.1038/s41569-020-0400-1 NLM32587347 146931501 ppf: 790 ppct: 17 formats: tig: atl: Coronary vessel formation in development and disease: mechanisms and insights for therapy. aug: au: Lupu, Irina-Elena De Val, Sarah Smart, Nicola affil: British Heart Foundation Centre of Regenerative Medicine, Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK sug: subj: Myocardial Infarction Therapy Coronary Vessels Physiology Regeneration Funding Source ab: The formation of new blood vessels after myocardial infarction (MI) is essential for the survival of existing and regenerated cardiac tissue. However, the extent of endogenous revascularization after MI is insufficient, and MI can often result in ventricular remodelling, progression to heart failure and premature death. The neutral results of numerous clinical trials that have evaluated the efficacy of angiogenic therapy to revascularize the infarcted heart reflect our poor understanding of the processes required to form a functional coronary vasculature. In this Review, we describe the latest advances in our understanding of the processes involved in coronary vessel formation, with mechanistic insights taken from developmental studies. Coronary vessels originate from multiple cellular sources during development and form through a number of distinct and carefully orchestrated processes. The ectopic reactivation of developmental programmes has been proposed as a new paradigm for regenerative medicine, therefore, a complete understanding of these processes is crucial. Furthermore, knowledge of how these processes differ between the embryonic and adult heart, and how they might be more closely recapitulated after injury are critical for our understanding of regenerative biology, and might facilitate the identification of tractable molecular targets to therapeutically promote neovascularization and regeneration of the infarcted heart. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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