Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort.
Purpose: Dietary intakes are reflected in plasma by the presence of hundreds of exogenous metabolites and variations in endogenous metabolites. The exploration of diet-related plasma metabolic profiles could help to better understand the impact of overall diet on health. Our aim was to identify meta...
| Publicado en: | European Journal of Nutrition Vol. 59; no. 8; pp. 3425 - 3440 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147018941&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147018941 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2020 vid: 59 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 147018941 144122990 147018941 147018941 10.1007/s00394-020-02177-5 147018941 ppf: 3425 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort. aug: au: Lécuyer, Lucie Dalle, Céline Micheau, Pierre Pétéra, Mélanie Centeno, Delphine Lyan, Bernard Lagree, Marie Galan, Pilar Hercberg, Serge Rossary, Adrien Demidem, Aicha Vasson, Marie-Paule Partula, Valentin Deschasaux, Mélanie Srour, Bernard Latino-Martel, Paule Druesne-Pecollo, Nathalie Kesse-Guyot, Emmanuelle Durand, Stéphanie Pujos-Guillot, Estelle affil: Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm) U1153, French National Institute for Agricultural Research (Inra) U1125, French National Conservatory of Arts and Crafts (Cnam), Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017, Bobigny Cedex, France sug: subj: Women Diet Plasma Metabolism Metabolomics Food Intake Nutritional Physiology Human Women's Health Cross Sectional Studies Female Factor Analysis Chromatography, High Pressure Liquid Multiple Sclerosis Multiple Logistic Regression Correlational Studies Health Food Female ab: Purpose: Dietary intakes are reflected in plasma by the presence of hundreds of exogenous metabolites and variations in endogenous metabolites. The exploration of diet-related plasma metabolic profiles could help to better understand the impact of overall diet on health. Our aim was to identify metabolomic signatures reflecting overall diet in women from the French general population. Methods: This cross-sectional study included 160 women in the SU.VI.MAX cohort with detailed dietary data (≥ 10 24-h dietary records) selected according to their level of adherence to the French dietary recommendations, represented by the validated score mPNNS-GS; 80 women from the 10th decile of the score were matched with 80 women from the 1st decile. Plasma metabolomic profiles were acquired using untargeted UPLC-QToF mass spectrometry analysis. The associations between metabolomic profiles and the mPNNG-GS, its components and Principal Component Analyses-derived dietary patterns were investigated using multivariable conditional logistic regression models and partial correlations. Results: Adherence to the dietary recommendations was positively associated with 3-indolepropionic acid and pipecolic acid (also positively associated with fruit and vegetable intake and a healthy diet)—2 metabolites linked to microbiota and inversely associated with lysophosphatidylcholine (LysoPC(17:1)), acylcarnitine C9:1 (also inversely associated with a healthy diet), acylcarnitine C11:1 and 2-deoxy-D-glucose. Increased plasma levels of piperine and Dihydro4mercapto-3(2H) furanone were observed in women who consumed a Western diet and a healthy diet, respectively. Ethyl-β-D-glucopyranoside was positively associated with alcohol intake. Plasma levels of LysoPC(17:1), cholic acid, phenylalanine-phenylalanine and phenylalanine and carnitine C9:1 decreased with the consumption of vegetable added fat, sweetened food, milk and dairy products and fruit and vegetable intakes, respectively. Conclusion: This study highlighted several metabolites from both host and microbial metabolism reflecting the long-term impact of the overall diet. Trial registration: SU.VI.MAX, clinicaltrials.gov NCT00272428. Registered 3 January 2006, https://clinicaltrials.gov/show/NCT00272428 pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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