A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China.
Background and aims: Iodine is one of the most important trace elements in the human body. It is not only the main component of thyroid hormones but also has extrathyroid biological functions. To date, there have been no large-scale epidemiological studies on the relationship between hyperuricemia a...
| Publicado en: | European Journal of Nutrition Vol. 59; no. 8; pp. 3659 - 3669 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147018960&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147018960 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2020 vid: 59 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 147018960 143980331 147018960 147018960 10.1007/s00394-020-02199-z 147018960 ppf: 3659 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China. aug: au: Lu, Xixuan Shi, Xiaoguang Li, Yanbo Chi, Haiyi Liao, Eryuan Liu, Chao Liu, Libin Li, Yongze Teng, Di Teng, Xiaochun Ba, Jianming Chen, Bing Du, Jianling He, Lanjie Lai, Xiaoyang Qin, Guijun Qin, Yingfen Quan, Huibiao Shi, Bingyin Sun, Hui affil: The Institute of Endocrinology, The First Hospital of China Medical University, No. 155, Nanjing Bei Street, 110001, Shenyang, Liaoning, People's Republic of China sug: subj: Iodine Urine Hyperuricemia Epidemiology Gout Epidemiology Iodine Therapeutic Use Human Cross Sectional Studies China Adult Adolescence Multi-Stage Cluster Random Assignment Uric Acid Blood Postmenopause Premenopause Chi Square Test Descriptive Statistics Odds Ratio Confidence Intervals Adult: 19-44 years Adolescent: 13-18 years ab: Background and aims: Iodine is one of the most important trace elements in the human body. It is not only the main component of thyroid hormones but also has extrathyroid biological functions. To date, there have been no large-scale epidemiological studies on the relationship between hyperuricemia and iodine intake, although both are closely related to health. A population-based epidemiological survey in China offers such an opportunity. Methods: This population-based cross-sectional study recruited 75,653 adults aged ≥ 18 years from 2015 to 2017 with a randomized, multistage, stratified sampling strategy. Serum uric acid levels and urinary iodine concentrations (UICs) were measured. Results: Stratified by UIC, the prevalence of hyperuricemia was 17.8%, 18.8%, 16.0% and 13.7% in the UIC < 100, 100–199, 200–299, and ≥ 300 μg/L groups, respectively; the prevalence of gout was 4.0%, 3.4%, 2.4% and 1.7%, respectively. The prevalence of gout decreased significantly as the UIC increased. The prevalence of hyperuricemia and gout were markedly higher in postmenopausal females than in the premenopausal population (hyperuricemia: 15.9% vs. 8.3%, X2 = 520.072, p < 0.001; gout: 3.6% vs. 1.3%, X2 = 219.889, p < 0.001), and the prevalence decreased as the UIC increased. Subjects in the more than adequate and excessive iodine groups had lower likelihoods of having hyperuricemia [aOR = 0.81 (95% CI 0.77–0.85), aOR = 0.68 (95% CI 0.64–0.72)] and lower odds of having gout than subjects in the adequate iodine (AI) group [aOR = 0.77 (95% CI 0.68–0.86), aOR = 0.59 (95% CI 0.51–0.68)]. Conclusions: UIC was inversely associated with the occurrence of hyperuricemia and gout. More in-depth research and prospective studies are needed to explore the molecular mechanisms and confirm the observed association. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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