Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases.
Purpose: The research goal is to develop dietary strategies to help address the growing incidence of inflammatory bowel diseases (IBD). This study has investigated the effectiveness of green banana resistant starch (GBRS) and probiotic Bacillus coagulans MTCC5856 spores for the amelioration of dextr...
| Publicado en: | European Journal of Nutrition Vol. 59; no. 8; pp. 3669 - 3690 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147018961&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147018961 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2020 vid: 59 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 147018961 143916321 147018961 147018961 10.1007/s00394-020-02200-9 147018961 ppf: 3669 ppct: 21 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases. aug: au: Shinde, Tanvi Perera, Agampodi Promoda Vemuri, Ravichandra Gondalia, Shakuntla V. Beale, David J. Karpe, Avinash V. Shastri, Sonia Basheer, Waheedha Southam, Benjamin Eri, Rajaraman Stanley, Roger affil: Centre for Food Safety and Innovation, Tasmanian Institute of Agriculture, University of Tasmania, 7250, Launceston, TAS, Australia sug: subj: Inflammatory Bowel Diseases Diet Therapy Prebiotics Pharmacodynamics Probiotics Pharmacodynamics Glucans Therapeutic Use Banana Bacillus Dietary Supplementation Drug Therapy, Combination Animal Studies Mice Colitis Diet Therapy Severity of Illness Indices Proteins Gene Expression Drug Effects Interleukins Drug Effects Interleukins Blood C-Reactive Protein Blood Fatty Acids Metabolism ab: Purpose: The research goal is to develop dietary strategies to help address the growing incidence of inflammatory bowel diseases (IBD). This study has investigated the effectiveness of green banana resistant starch (GBRS) and probiotic Bacillus coagulans MTCC5856 spores for the amelioration of dextran-sulfate sodium (DSS)-induced colitis in mice. Methods: Eight-week-old C57BL/6 mice were fed standard rodent chow diet supplemented with either B. coagulans, GBRS or its synbiotic combination. After 7 days supplementation, colitis was induced by adding 2% DSS in drinking water for 7 days while continuing the supplemented diets. Animal health was monitored and after 14 days all animals were sacrificed to measure the biochemical and histochemical changes associated with each supplement type. Results: The disease activity index and histological damage score for DSS-control mice (6.1, 17.1, respectively) were significantly higher (p < 0.0001) than the healthy mice. Synbiotic supplementation alleviated these markers (− 67%, − 94% respectively) more adequately than B. coagulans (− 52%, − 58% respectively) or GBRS (− 57%, − 26%, respectively) alone. Compared to DSS-control synbiotic supplementation significantly (p < 0.0001) maintained expressions of tight junction proteins. Moreover, synbiotic effects accounted for ~ 40% suppression of IL-1β and ~ 29% increase in IL-10 levels in serum while also reducing C-reactive protein (− 37%) compared to that of the DSS-control. While, B. coagulans alone could not induce additional levels of short-chain fatty acid (SCFA) production beyond the caecum, the synbiotic combination with GBRS resulted in substantial increased SCFA levels across the whole length of the colon. Conclusion: The synbiotic supplementation with B. coagulans and GBRS ameliorated the overall inflammatory status of the experimental IBD model via synergistic functioning. This supports researching its application in mitigating inflammation in human IBD. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|