Consumption of salt leads to ameliorate symptoms of metabolic disorder and change of gut microbiota.
Purpose: Metabolic diseases caused by high-carbohydrate and/or high-salt diets are becoming major public health concerns. However, the effects of salt on high-carbohydrate diet-induced obesity are unclear. Accordingly, in this study, we investigated the effects of high-salt intake on high-carbohydra...
| Publicado en: | European Journal of Nutrition Vol. 59; no. 8; pp. 3779 - 3791 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147018969&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147018969 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2020 vid: 59 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 147018969 143962679 147018969 147018969 10.1007/s00394-020-02209-0 147018969 ppf: 3779 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Consumption of salt leads to ameliorate symptoms of metabolic disorder and change of gut microbiota. aug: au: Do, Moon Ho Lee, Hye-Bin Oh, Mi-Jin Jhun, Hyunjhung Ha, Sang Keun Park, Ho-Young affil: Research Division of Food Functionality, Korea Food Research Institute, 55365, Wanju-gun, Jeollabuk-do, Republic of Korea sug: subj: Sodium Chloride, Dietary Food Intake Signs and Symptoms Prevention and Control Metabolic Diseases Prevention and Control Gut Microbiota Metabolism Obesity Chemically Induced Dietary Carbohydrates Metabolism Animal Studies Models, Biological Mice Rice Diet RNA Analysis Insulin Resistance Metabolism Glucose Metabolism Blotting, Western Histological Techniques Lipids Metabolism In Vitro Studies Adipose Tissue Metabolism Body Weight Inflammation Liver Metabolism Peroxisome Proliferator-Activated Receptors Metabolism Proteins Metabolism Adiponectin Metabolism ab: Purpose: Metabolic diseases caused by high-carbohydrate and/or high-salt diets are becoming major public health concerns. However, the effects of salt on high-carbohydrate diet-induced obesity are unclear. Accordingly, in this study, we investigated the effects of high-salt intake on high-carbohydrate diet-induced obesity. Methods: We performed a 12-week study on gut microbiota and metabolic changes in high-rice diet (HRD) or HRD supplemented with high-salt (HRS)-fed C57BL/6 J mice by 16S rRNA analysis, glucose and insulin tolerance testing, gut barrier function, western blot and histological analysis. Moreover, the effects of salt on lipid metabolism were confirmed in vitro using 3T3-L1 cells. Results: High salt intake decreased HRD-induced increases in body and white adipose tissue (WAT) weight. Alternatively, HRS did not reverse the observed increases in glucose intolerance and insulin resistance. Moreover, HRD caused changes in the gut microbiota, thereby impairing gut barrier function and increasing inflammation in the liver. HRS altered HRD-induced microbial composition, however, did not ameliorate gut barrier dysfunction or hepatic inflammation. HRS diets regulated the HRD-induced increase in peroxisome proliferator-activated receptor-γ (PPAR-γ) and lipid metabolism-related protein expression. Moreover, within WAT, HRS was found to reverse the observed decrease in adiponectin and increase in PPAR-γ expression induced by HRD. In vitro, high NaCl concentration also significantly reduced 3T3-L1 cell differentiation and modulated lipid metabolism without causing cytotoxicity. Conclusion: These results indicate that high salt intake ameliorates metabolic changes associated with a high-rice diet, including changes in fecal microbiota composition. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|