Which obstacle attributes place additional demands on higher-level cognitive function in patients with Parkinson's disease?
Background: Previous reports show that patients with Parkinson's disease (PD) rely on prefrontal activation to compensate for impaired motor function during complex activities such as obstacle negotiation. However, the influence of the properties of the obstacles on prefrontal activation has not bee...
| Publicado en: | Parkinsonism & Related Disorders Vol. 78; pp. 178 - 184 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Sep2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147114580&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147114580 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13538020 JNO jtl: Parkinsonism & Related Disorders issn: 13538020 maglogo: N pubinfo: dt: Sep2020 vid: 78 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 147114580 147114580 NLM32927415 147114580 10.1016/j.parkreldis.2020.08.002 NLM32927415 147114580 ppf: 178 ppct: 6 formats: tig: atl: Which obstacle attributes place additional demands on higher-level cognitive function in patients with Parkinson's disease? aug: au: Sharon, T. Kurz, I. Bernad-Elazari, H. Shustak, S. Galperin, I. Giladi, N. Mirelman, A. Hausdorff, J.M. Maidan, I. affil: Laboratory of Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel sug: subj: Frontal Lobe Physiopathology Mental Processes Parkinson Disease Physiopathology Spatial Perception Psychomotor Performance Motor Activity Physiology Human Brain Mapping Aged, 80 and Over Aged Middle Age Parkinson Disease Complications Female Spectroscopy, Near-Infrared Male Comparative Studies Multicenter Studies Evaluation Research Validation Studies Short Portable Mental Status Questionnaire Clinical Assessment Tools Aged, 80 & over Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: Previous reports show that patients with Parkinson's disease (PD) rely on prefrontal activation to compensate for impaired motor function during complex activities such as obstacle negotiation. However, the influence of the properties of the obstacles on prefrontal activation has not been systematically evaluated. Here, we examined the effects of obstacle height and anticipation time on prefrontal activation in patients with PD and older adults.Methods: 34 patients with PD (age: 67.4 ± 5.7 years; 14 women) and 26 older adults (age: 71.3 ± 8.9 years; 11 women) walked in an obstacle course while negotiating anticipated and unanticipated obstacles (long/short available time response, ART) at heights of 50 mm and 100 mm. Prefrontal activation was measured using functional Near-Infrared Spectroscopy (fNIRS); obstacle negotiation performance was measured using Kinect cameras.Results: PD patients showed greater increases in prefrontal activation during and after obstacle crossing compared to the older adults (p < 0.001). Obstacle height affected prefrontal activity only when crossing anticipated obstacles (ARTxheight interaction, p = 0.011), in which case higher obstacles were accompanied by higher prefrontal activity. PD patients showed higher levels of activation during unanticipated obstacles, compared to older adults (groupXART: p = 0.015). Different correlations between prefrontal activation and obstacle negotiation strategies were observed in patients and controls.Conclusions: These results point to the use of prefrontal activation as a compensatory mechanism in PD. Moreover, the higher activation observed when negotiating more challenging obstacles suggests that there is greater reliance on cognitive resources in these demanding situations that may contribute to the higher risk of falls in PD patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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