Periodic normalization of the translaminar pressure gradient prevents glaucomatous damage.
The 24-hour intraocular pressure (IOP) rhythm is of interest to clinicians but its overall impact on glaucomatous progression remains unclear. Recent evidence has implicated the translaminar pressure gradient (TLPG), or imbalance between IOP and intracranial pressure, in the development of glaucoma....
| Publicado en: | Medical Hypotheses Vol. 144 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Nov2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147116267&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147116267 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03069877 NZO jtl: Medical Hypotheses issn: 03069877 maglogo: N pubinfo: dt: Nov2020 vid: 144 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 147116267 147116267 NLM33254565 10.1016/j.mehy.2020.110258 NLM33254565 147116267 ppct: 1 formats: tig: atl: Periodic normalization of the translaminar pressure gradient prevents glaucomatous damage. aug: au: Berdahl, John P. Ferguson, Tanner J. Samuelson, Thomas W. affil: Vance Thompson Vision, Sioux Falls, SD, United States sug: subj: Glaucoma Prevention and Control Intracranial Pressure Retina Intraocular Pressure Impact of Events Scale ab: The 24-hour intraocular pressure (IOP) rhythm is of interest to clinicians but its overall impact on glaucomatous progression remains unclear. Recent evidence has implicated the translaminar pressure gradient (TLPG), or imbalance between IOP and intracranial pressure, in the development of glaucoma. Evidence suggests that retinal ganglion cell death occurs as a result of decreased axonal transport only after a sustained, elevated TLPG. We hypothesize that periodic normalization of the TLPG prevents glaucomatous damage by enabling temporary resumption of axonal transport. Temporary resumption of axonal transport allows for delivery of critical metabolic cargoes with concomitant removal of metabolic waste which prevents apoptosis of the retinal ganglion cell. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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