The effects of nicotine and cannabis co-use during adolescence and young adulthood on white matter cerebral blood flow estimates.
Rationale: Co-use of cannabis and nicotine is common among adolescents/young adults and is associated with poorer psychological and physical outcomes, compared with single substance use. Little is known about the impact of co-use on the developing brain. Objectives: Preliminary investigation of the...
| Publicado en: | Psychopharmacology Vol. 237; no. 12; pp. 3615 - 3625 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147157238&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147157238 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: 2020 vid: 237 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 147157238 10.1007/s00213-020-05640-7 147157238 ppf: 3615 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The effects of nicotine and cannabis co-use during adolescence and young adulthood on white matter cerebral blood flow estimates. aug: au: Courtney, Kelly E. Baca, Rachel Doran, Neal Jacobson, Aaron Liu, Thomas T. Jacobus, Joanna affil: Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, MC 0405, 92093, La Jolla, CA, USA sug: ab: Rationale: Co-use of cannabis and nicotine is common among adolescents/young adults and is associated with poorer psychological and physical outcomes, compared with single substance use. Little is known about the impact of co-use on the developing brain. Objectives: Preliminary investigation of the effects of nicotine on white matter (WM) cerebral blood flow (CBF) in adolescents/young adults and its potential moderation by cannabis use. Methods: Adolescent/young adult (16–22 years old) nicotine and tobacco product users (NTP; N = 37) and non-nicotine users (non-NTP; N = 26) underwent a neuroimaging session comprised of anatomical, optimized pseudo-continuous arterial spin labeling, and diffusion tensor imaging scans. Groups were compared on whole-brain WM CBF estimates and their relation to past-year cannabis use. Follow-up analyses assessed correlations between identified CBF clusters and corresponding fractional anisotropy (FA) values. Results: Group by cannabis effects were observed in five clusters (voxel-wise alpha < 0.001, cluster-wise alpha < 0.05; ≥ 11 contiguous voxels): non-NTP exhibited positive correlations between CBF and cannabis use in all clusters, whereas no significant relationships were observed for NTP. Greater CBF extracted from one cluster (including portions of right superior longitudinal fasciculus) was associated with reduced FA for non-NTP group only. Conclusions: This is the first investigation of WM health as indexed by CBF, and its association with FA, in adolescents/young adults with nicotine and/or cannabis use. Results suggest that cannabis use by itself may be related to increased CBF in WM fiber tracts demonstrating poorer structural intergrity, yet the occurrence of even infrequent NTP use (greater than once per month) appears to diminish this relationship. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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