The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia.
Background: Dyspeptic syndrome is particularly common in postmenopausal women in the form of epigastric pain. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, and examine the role of Helicobacter infection.Methods: The study comprised 152 subjects...
| Publicado en: | BMC Women's Health Vol. 20; no. 1 |
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| Autores principales: | , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
BioMed Central
11/26/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147225298&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147225298 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726874 1CIP jtl: BMC Women's Health issn: 14726874 maglogo: N pubinfo: dt: 11/26/2020 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 147225298 147225298 NLM33243209 147225298 10.1186/s12905-020-01117-z NLM33243209 147225298 ppct: 1 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia. aug: au: Chojnacki, Cezary Mędrek-Socha, Marta Konrad, Paulina Chojnacki, Jan Błońska, Aleksandra affil: Department of Clinical Nutrition and Gastroenterological Diagnostics of Medical University, Lodz, Poland sug: subj: Helicobacter Infections Drug Therapy Helicobacter Pylori Dietary Supplements Dyspepsia Drug Therapy Dyspepsia Microbiology Melatonin Therapeutic Use Female Human Aged Treatment Outcomes Middle Age Postmenopause Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Randomized Controlled Trials Random Assignment Aged: 65+ years Middle Aged: 45-64 years Female ab: Background: Dyspeptic syndrome is particularly common in postmenopausal women in the form of epigastric pain. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, and examine the role of Helicobacter infection.Methods: The study comprised 152 subjects including 30 healthy women (Group I), 60 women with asymptomatic H.pylori infection (Group II), and 64 women with H. pylori infection with chronic dyspepsia (Group III). Endoscopic examination was performed, as well as histological assessment of gastric end duodenal mucosa, urease breath test (UBT-13C), and immunoenzymatic assessment of serum 17-β-estradiol, follicle stimulating hormone and melatonin, and urinary 6-sulfatoxymelatonin. In Group III, 14-day antibacterial treatment was introduced with pantoprazole, amoxicillin and levofloxacin followed a six-month treatment with placebo in 32 women (Group IIIa), and melatonin 1 mg/morning and 3 mg/at bedtime in the other 32 women (Group IIIb).Results: No significant differences were found between serum level of female hormone. Serum melatonin levels were similar between Group I (12.5 ± 2.72 pg/ml) and Group II (10.5 ± 3.73 pg/ml; p > 0,05). The level was significantly lower in Group III (5.72 ± 1.42 pg/ml; p < 0.001). Eradication of H.pylori was obtained in 75.0% women in Group IIIa, and in 84.3% in Group IIIb (p > 0.05). After six months, dyspeptic symptoms resolved in 43.7% patients in Group IIIa and 84.3% in Group IIIb (p < 0.001).Conclusion: Melatonin supplementation is useful in treating H. pylori-associated dyspepsia, particularly in postmenopausal women with lower levels of this hormone.Trial Registration: NCT04352062, date of registration: 15.04.2020. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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