Influence of Early Bladder Imaging in Experimental Rabbits on the Quantitative Determination of Glomerular Filtration Rate by the Gates Method.
Objective. To investigate the influence of early bladder imaging (EBI) in experimental rabbits on the quantitative calculation of glomerular filtration rate (GFR) by the Gates method. Methods. We retrospectively analyzed the data of dynamic renal scintigraphy (DRS) in experimental rabbits. We calcul...
| Publicado en: | BioMed Research International pp. 1 - 14 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
11/28/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147265240&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147265240 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 11/28/2020 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 147265240 147265240 147265240 10.1155/2020/8848189 147265240 ppf: 1 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Influence of Early Bladder Imaging in Experimental Rabbits on the Quantitative Determination of Glomerular Filtration Rate by the Gates Method. aug: au: Wang, Changyin Li, Shun Gao, Chun Maimaiti, Wasili Yang, Qisheng Jiang, Linglong affil: Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China sug: subj: Glomerular Filtration Rate Evaluation Bladder Diagnostic Imaging Animal Studies Rabbits Models, Biological Retrospective Design Radionuclide Imaging Descriptive Statistics ab: Objective. To investigate the influence of early bladder imaging (EBI) in experimental rabbits on the quantitative calculation of glomerular filtration rate (GFR) by the Gates method. Methods. We retrospectively analyzed the data of dynamic renal scintigraphy (DRS) in experimental rabbits. We calculated renal uptake during minutes 1-2 and 2-3 by correcting bladder radioactivity and computed the split GFR by renal uptake. Then, the EBI and GFR between 1-2 min and 2-3 min were compared, respectively. Results. The EBI proportion (57.3%) at 2-3 min of DRS was higher than that (8.5%) at 1-2 min (P < 0.05). The correlations between the 1-2 min and 2-3 min uptake rates of unobstructed kidneys after correction (r = 0.952 ‐ 0.979) were higher than those before correction (r = 0.859 ‐ 0.936). However, the correlation between the two in obstructed kidneys was not improved ( r before = 0.967 versus r after = 0.968). For unobstructed kidneys, the difference in GFR based on 2-3 min uptake between before and after correction was significant (P < 0.05), but not in obstructed kidneys (P > 0.05). For GFR based on 1-2 min uptake, the difference between before and after correction was not significant in obstructed or unobstructed kidneys (P > 0.05). Before correction, the GFR of unobstructed kidneys of 10.5% of the rabbits in the protein load test was lower than that in the baseline status, but not so after correction. Conclusion. The 2-3 min EBI on DRS has a significant influence on the GFR calculated by the Gates method in experimental rabbits. Controlling water intake or calculating the GFR by 1-2 min renal uptake helps to avoid the influence of EBI on GFR. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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