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The clinical characteristics and outcome of cryptococcal meningitis with AIDS in a tertiary hospital in China: an observational cohort study.

Background: Despite the profound impact of antiretroviral therapy in the control of AIDS mortality, central nervous system opportunistic infections remains a significant burden in AIDS patients. This retrospective study aims to elucidate the clinical characteristics, outcome and risk factors of cryp...

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Published in:BMC Infectious Diseases Vol. 20; no. 1
Main Authors: Wu, Liang, Xiao, Jiang, Song, Yangzi, Gao, Guiju, Zhao, Hongxin
Format: Journal Article
Published: BioMed Central 12/1/2020
Online Access:View this record in EBSCOhost
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      dt: 12/1/2020
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      pub: BioMed Central
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        147314636
        147314636
        NLM33261581
        10.1186/s12879-020-05661-9
        NLM33261581
        147314636
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        atl: The clinical characteristics and outcome of cryptococcal meningitis with AIDS in a tertiary hospital in China: an observational cohort study.
      aug:
        au:
          Wu, Liang
          Xiao, Jiang
          Song, Yangzi
          Gao, Guiju
          Zhao, Hongxin
        affil: Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
      sug:
        subj:
          Cryptococcus Immunology
          AIDS-Related Opportunistic Infections Complications
          Anti-HIV Agents Therapeutic Use
          AIDS-Related Opportunistic Infections Drug Therapy
          Meningitis, Cryptococcal Complications
          HIV-1 Immunology
          Incidence
          Meningitis, Cryptococcal Microbiology
          Risk Factors
          Meningitis, Cryptococcal Cerebrospinal Fluid
          Treatment Outcomes
          Adolescence
          Female
          Hospitalization
          Prognosis
          AIDS-Related Opportunistic Infections
          Retrospective Design
          Infarction Epidemiology
          Aged
          Male
          Hospitals, Special
          AIDS-Related Opportunistic Infections Epidemiology
          Meningitis, Cryptococcal Epidemiology
          Infarction Microbiology
          Middle Age
          Adult
          Young Adult
          China
          Antibodies, Viral Immunology
          Cryptococcus
          Arthritis Impact Measurement Scales
          Impact of Events Scale
          Scales
          Adolescent: 13-18 years
          Aged: 65+ years
          Middle Aged: 45-64 years
          Adult: 19-44 years
          Female
          Male
      ab: Background: Despite the profound impact of antiretroviral therapy in the control of AIDS mortality, central nervous system opportunistic infections remains a significant burden in AIDS patients. This retrospective study aims to elucidate the clinical characteristics, outcome and risk factors of cryptococcal meningitis (CM) poor prognosis in AIDS patients from a tertiary hospital in China.Methods: Clinical data from 128 patients admitted in Beijing Ditan Hospital, Capital Medical University from November 2008 to November 2017 was collected. The cohort was stratified based on treatment outcome (effective 79%, and ineffective 21%), and Multivariate Logistic regression analysis used to identify risk factors of poor disease prognosis.Results: Age, incidence of cerebral infarction, the proportion of consciousness disorder, and fasting plasma glucose was higher in the ineffective treatment group than the effective treatment group. The duration of treatment in the induction period of the ineffective group was significantly shorter than that of the effective group. Multivariate Logistic regression analysis indicated that the occurrence of cerebral hernia and consciousness disorder were risk factors for the prognosis of AIDS patients with CM infection, while the duration of treatment in the induction period was a indicative of a better prognosis in AIDS with CM infection complications. Finally, shunt decompression therapy correlated with a better disease outcome.Conclusions: This retrospective study exposes the main risk factors associated with worse disease prognosis in AIDS patients with CM infection complications.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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