Comparison of diagnostic performance between diffusion kurtosis imaging parameters and mono-exponential ADC for determination of clinically significant cancer in patients with prostate cancer.
Purpose: To compare the diagnostic performance between diffusion kurtosis imaging (DKI) parameters and mono-exponential apparent diffusion coefficient (ADC) for determination of clinically significant cancer (CSC, Gleason score (GS) ≥ 7) in patients with histologically proven prostate cancer (PCa)....
| Published in: | Abdominal Radiology Vol. 45; no. 12; pp. 4235 - 4244 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Dec2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147338376&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147338376 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Dec2020 vid: 45 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 147338376 146025384 10.1007/s00261-020-02776-0 147338376 ppf: 4235 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparison of diagnostic performance between diffusion kurtosis imaging parameters and mono-exponential ADC for determination of clinically significant cancer in patients with prostate cancer. aug: au: Park, Hyungin Kim, Seung Ho Lee, Yedaun Son, Jung Hee affil: Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Haeundae-ro 875, Haeundae-gu, 48108, Busan, Korea sug: ab: Purpose: To compare the diagnostic performance between diffusion kurtosis imaging (DKI) parameters and mono-exponential apparent diffusion coefficient (ADC) for determination of clinically significant cancer (CSC, Gleason score (GS) ≥ 7) in patients with histologically proven prostate cancer (PCa). Methods: A total of 92 patients (mean age: 71.5 years, range: 47–89 years) who had been diagnosed as PCa and undergone 3 T-MRI including DWI (b values, 0, 100, 1000, 2000s/mm2) were included in this study. The DKI parameters, namely apparent diffusion for non-Gaussian distribution (Dapp) and apparent kurtosis coefficient (Kapp), were calculated by dedicated software using mono-exponential and diffusion kurtosis models for quantitation. The measurement was performed for a whole tumor after segmentation, and pathologic topographic maps or systemic biopsy results served as the reference standard for segmentation. To compare the diagnostic performance of each parameter for determination of CSC, pair-wise comparison of receiver operating characteristic (ROC) curves was performed. Results: The study population consisted of GS 6 (n = 18), GS 7 (n = 31), GS 8 (n = 25), GS 9 (n = 15) and GS 10 (n = 3) patients. The area under the ROC curve of Kapp (0.707, 95% CI 0.603–0.798) for discriminating CSC from non-CSC was not significantly different from those of mono-exponential ADC (0.725, 0.622–0.813, P = 0.2175) or Dapp (0.726, 0.623–0.814, P = 0.9628). Diagnostic predictive values of Kapp were estimated to a maximum accuracy of 78%, a sensitivity of 86%, and a specificity of 47%, while those of mono-exponential ADC were 75, 81, and 53%, respectively. Conclusion: The DKI parameters showed a diagnostic performance comparable to mono-exponential ADC for determination of CSC in patients with PCa. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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