Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system.

Background: Breast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integrins/integrin-linked kinase signalling are upregulated.Methods: We investigated this in two patient-derived xenografts (PDXs) developed from breast-to-bone metastases, and...

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Publicado en:	Breast Cancer Research Vol. 22; no. 1; pp. 1 - 22
Autores principales:	Wafai, Razan, Williams, Elizabeth D., de Souza, Emma, Simpson, Peter T., McCart Reed, Amy E., Kutasovic, Jamie R., Waltham, Mark, Snell, Cameron E., Blick, Tony, Thompson, Erik W., Hugo, Honor J.
Formato:	research Journal Article
Publicado:	BioMed Central 12/4/2020
Acceso en línea:	Ver este registro en EBSCOhost