Changes in Gut Microbiome Associated With Co-Occurring Symptoms Development During Chemo-Radiation for Rectal Cancer: A Proof of Concept Study.
Purpose: To examine a) whether there are significant differences in the severity of symptoms of fatigue, sleep disturbance, or depression between patients with rectal cancer who develop co-occurring symptoms and those with no symptoms before and at the end of chemotherapy and radiation therapy (CRT)...
| Publicado en: | Biological Research for Nursing Vol. 23; no. 1; pp. 31 - 42 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jan2021
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147578627&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147578627 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10998004 5WE jtl: Biological Research for Nursing issn: 10998004 maglogo: Y pubinfo: dt: Jan2021 vid: 23 iid: 1 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 147578627 146261590 147578627 147578627 10.1177/1099800420942830 147578627 ppf: 31 ppct: 11 formats: tig: atl: Changes in Gut Microbiome Associated With Co-Occurring Symptoms Development During Chemo-Radiation for Rectal Cancer: A Proof of Concept Study. aug: au: González-Mercado, Velda J. Henderson, Wendy A. Sarkar, Anujit Lim, Jean Saligan, Leorey N. Berk, Lawrence Dishaw, Larry McMillan, Susan Groer, Maureen Sepehri, Farrah Melkus, Gail D'Eramo affil: NYU Rory Meyers College of Nursing, New York, NY, USA sug: subj: Rectal Neoplasms Drug Therapy Rectal Neoplasms Radiotherapy Chemotherapy, Cancer Rectal Neoplasms Symptoms Fatigue Sleep Disorders Depression Gut Microbiota Treatment Outcomes Human Male Female Descriptive Statistics Mann-Whitney U Test Data Analysis Software Random Forest Southeastern United States Wilcoxon Rank Sum Test Middle Age Aged Funding Source Clinical Assessment Tools Scales Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: To examine a) whether there are significant differences in the severity of symptoms of fatigue, sleep disturbance, or depression between patients with rectal cancer who develop co-occurring symptoms and those with no symptoms before and at the end of chemotherapy and radiation therapy (CRT); b) differences in gut microbial diversity between those with co-occurring symptoms and those with no symptoms; and c) whether before-treatment diversity measurements and taxa abundances can predict co-occurrence of symptoms. Methods: Stool samples and symptom ratings were collected from 31 patients with rectal cancer prior to and at the end of (24–28 treatments) CRT. Descriptive statistics were computed and the Mann-Whitney U test was performed for symptoms. Gut microbiome data were analyzed using R's vegan package software. Results: Participants with co-occurring symptoms reported greater severity of fatigue at the end of CRT than those with no symptoms. Bacteroides and Blautia2 abundances differed between participants with co-occurring symptoms and those with no symptoms. Our random forest classification (unsupervised learning algorithm) predicted participants who developed co-occurring symptoms with 74% accuracy, using specific phylum, family, and genera abundances as predictors. Conclusion: Our preliminary results point to an association between the gut microbiota and co-occurring symptoms in rectal cancer patients and serves as a first step in potential identification of a microbiota-based classifier. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|