Comparative efficacies of Calmare® therapy and transcutaneous electrical nerve stimulation in randomized peripheral neuropathy subjects with resting state fMRI monitoring.
Clinical reports of Calmare® protocol efficacy suggest enhanced durability compared to TENS and the possibility changes in resting fMRI connectivity. The objective was to compare peripheral neuropathy pain relief and resting fMRI changes with Calmare and TENS treatments. Randomized double-blind tria...
| Publicado en: | Journal of Pain Management Vol. 13; no. 2; pp. 149 - 167 |
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| Autores principales: | , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Nova Science Publishers, Inc.
2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147588057&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147588057 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19395914 903P jtl: Journal of Pain Management issn: 19395914 maglogo: N pubinfo: dt: 2020 vid: 13 iid: 2 pid: 1040 pub: Nova Science Publishers, Inc. place: Hauppauge, New York artinfo: ui: 147588057 147588057 147588057 147588057 ppf: 149 ppct: 18 formats: fmt: @attributes: type: P tig: atl: Comparative efficacies of Calmare® therapy and transcutaneous electrical nerve stimulation in randomized peripheral neuropathy subjects with resting state fMRI monitoring. aug: au: Bodily, Ty A. Edvalson, Logan Peacock, Jordan B. Bradshaw, Zack M. Hart, Carson Ernst, Cameron Biggs, Samuel Busath, David D. affil: Department of Physiology and Developmental Biology and Center for Neuroscience, Brigham Young University, Provo, Utah, USA sug: subj: Peripheral Nervous System Diseases Therapy Pain Management Methods Transcutaneous Electric Nerve Stimulation Magnetic Resonance Imaging Evaluation Monitoring, Physiologic Human Randomized Controlled Trials Hemodynamics Functional Connectivity Post Hoc Analysis Hippocampus Amygdala Physiology Pain ab: Clinical reports of Calmare® protocol efficacy suggest enhanced durability compared to TENS and the possibility changes in resting fMRI connectivity. The objective was to compare peripheral neuropathy pain relief and resting fMRI changes with Calmare and TENS treatments. Randomized double-blind trials performed in August 2015 and between August 2016 and November 2017, with eighteen and twenty human peripheral neuropathy subjects, respectively. The initial trial examined the effects of a single session while the latter trial examined the effects of a course of ten treatment sessions on consecutive weekdays. fMRI scans were examined for changes in blood flow correlations and connectivity. Subjective pain scores were similarly reduced by both Calmare and TENS treatments. In the ten-session study, the relief was prolonged, again similarly for both groups. The pain area relieved, which may be a more important metric than residual pain score, was reduced significantly more in the Calmare group than in it was reduced in the TENS group in post hoc analysis. After the treatment, resting fMRI showed an increase in global efficiency and in correlation of activity between left the hippocampus and theright amygdala for both treatment modalities. Treatment with Calmare or TENS yields prolonged pain reduction and correlates with reproducible fMRI changes. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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