EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR.
Long noncoding RNAs play an essential role in bladder cancer progression. The role of long noncoding RNA EGFR-AS1 in bladder cancer needs further study. We used clinical specimens to analyze the relationship between EGFR-AS1 and bladder cancer patients' characteristics. The functional experiments an...
| Publicado en: | BioMed Research International pp. 1 - 10 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
12/28/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147805034&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147805034 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 12/28/2020 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 147805034 147805034 147805034 10.1155/2020/6665974 147805034 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR. aug: au: Wang, Anbang Jiang, Aimin Gan, Xinxin Wang, Zheng Huang, Jinming Dong, Kai Liu, Bing Wang, Linhui Chen, Ming affil: Department of Urology, Changzheng Hospital, Naval Medical University, Shanghai 200003, China sug: subj: Bladder Neoplasms Metabolism Disease Progression RNA Pharmacodynamics Epidermal Growth Factor Receptors Drug Effects Human Polymerase Chain Reaction Methods Survival Analysis Correlational Studies RNA Metabolism Bladder Neoplasms Prognosis In Vivo Studies In Vitro Studies Cell Proliferation Drug Effects RNA, Messenger Drug Effects Bladder Neoplasms Immunology Epidermal Growth Factor Receptors Metabolism ab: Long noncoding RNAs play an essential role in bladder cancer progression. The role of long noncoding RNA EGFR-AS1 in bladder cancer needs further study. We used clinical specimens to analyze the relationship between EGFR-AS1 and bladder cancer patients' characteristics. The functional experiments and mechanism studies were performed using qRT-PCR, transwell assay, survival analysis, and correlation analysis. We found that high expression of EGFR-AS1 was nearly related to aggressive bladder cancer and indicated poor prognosis for patients. The functional experiments in vivo and in vitro suggested that EGFR-AS1 promoted the proliferation and invasion of bladder cancer cells. Mechanically, EGFR-AS1 promoted the expression of EGFR by inhibiting the degradation of EGFR mRNA, thereby promoting the metastasis of bladder cancer. In addition, EGFR-AS1/EGFR may be involved in the immune-related pathways of bladder cancer. These studies indicate that the EGFR-AS1/EGFR pathway may be a potential diagnostic marker and therapeutic target for bladder cancer. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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