Fully Balanced SSFP Without an Endorectal Coil for Postimplant QA of MRI-Assisted Radiosurgery (MARS) of Prostate Cancer: A Prospective Study.
Purpose: To investigate fully balanced steady-state free precession (bSSFP) with optimized acquisition protocols for magnetic resonance imaging (MRI)-based postimplant quality assessment of low-dose-rate (LDR) prostate brachytherapy without an endorectal coil (ERC).Methods and Materials: Seventeen p...
| Published in: | International Journal of Radiation Oncology, Biology, Physics Vol. 109; no. 2; pp. 614 - 626 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | clinical trial research Journal Article |
| Published: |
Pergamon Press - An Imprint of Elsevier Science
Feb2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147829593&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147829593 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03603016 1ZQ jtl: International Journal of Radiation Oncology, Biology, Physics issn: 03603016 maglogo: N pubinfo: dt: Feb2021 vid: 109 iid: 2 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 147829593 147829593 NLM32980498 147829593 10.1016/j.ijrobp.2020.09.040 NLM32980498 147829593 ppf: 614 ppct: 12 formats: tig: atl: Fully Balanced SSFP Without an Endorectal Coil for Postimplant QA of MRI-Assisted Radiosurgery (MARS) of Prostate Cancer: A Prospective Study. aug: au: Sanders, Jeremiah W. Venkatesan, Aradhana M. Levitt, Chad A. Bathala, Tharakeswara Kudchadker, Rajat J. Tang, Chad Bruno, Teresa L. Starks, Christine Santiago, Edwin Wells, Michelle Weaver, Carl P. Ma, Jingfei Frank, Steven J. affil: Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas sug: subj: Prostatic Neoplasms Magnetic Resonance Imaging Radiosurgery Equipment and Supplies Rectum Radiotherapy Equipment and Supplies Prostatic Neoplasms Radiotherapy Male Radiation Dosage Brachytherapy Equipment and Supplies Prospective Studies Sensitivity and Specificity Human Clinical Trials Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales Ferrans and Powers Quality of Life Index Male ab: Purpose: To investigate fully balanced steady-state free precession (bSSFP) with optimized acquisition protocols for magnetic resonance imaging (MRI)-based postimplant quality assessment of low-dose-rate (LDR) prostate brachytherapy without an endorectal coil (ERC).Methods and Materials: Seventeen patients at a major academic cancer center who underwent MRI-assisted radiosurgery (MARS) LDR prostate cancer brachytherapy were imaged with moderate, high, or very high spatial resolution fully bSSFP MRIs without using an ERC. Between 1 and 3 signal averages (NEX) were acquired with acceleration factors (R) between 1 and 2, with the goal of keeping scan times between 4 and 6 minutes. Acquisitions with R >1 were reconstructed with parallel imaging and compressed sensing (PICS) algorithms. Radioactive seeds were identified by 3 medical dosimetrists. Additionally, some of the MRI techniques were implemented and tested at a community hospital; 3 patients underwent MARS LDR prostate brachytherapy and were imaged without an ERC.Results: Increasing the in-plane spatial resolution mitigated partial volume artifacts and improved overall seed and seed marker visualization at the expense of reduced signal-to-noise ratio (SNR). The reduced SNR as a result of imaging at higher spatial resolution and without an ERC was partially compensated for by the multi-NEX acquisitions enabled by PICS. Resultant image quality was superior to the current clinical standard. All 3 dosimetrists achieved near-perfect precision and recall for seed identification in the 17 patients. The 3 postimplant MRIs acquired at the community hospital were sufficient to identify 208 out of 211 seeds implanted without reference to computed tomography (CT).Conclusions: Acquiring postimplant prostate brachytherapy MRI without an ERC has several advantages including better patient tolerance, lower costs, higher clinical throughput, and widespread access to precision LDR prostate brachytherapy. This prospective study confirms that the use of an ERC can be circumvented with fully bSSFP and advanced MRI scan techniques in a major academic cancer center and community hospital, potentially enabling postimplant assessment of MARS LDR prostate brachytherapy without CT. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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