Primary Immunoglobulin G4-Related Laryngeal Disease: A Case Series and Review of Literature.
Objective: Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognised cause of various systemic fibro-inflammatory conditions. However, laryngeal involvement as a primary feature is extremely rare. We aimed to report on a case series of such patients and examine the global literature...
| Publicado en: | Clinical Medicine Insights: Case Reports pp. 1 - 7 |
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| Autores principales: | , , , , , , , , |
| Formato: | case study pictorial tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jan-Dec2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147843468&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147843468 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795476 B3KM jtl: Clinical Medicine Insights: Case Reports issn: 11795476 maglogo: Y pubinfo: dt: Jan-Dec2020 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 147843468 147843468 147843468 10.1177/1179547620960197 147843468 ppf: 1 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Primary Immunoglobulin G4-Related Laryngeal Disease: A Case Series and Review of Literature. aug: au: Maughan, Elizabeth F Michaels, Joshua Miller, Benjamin Weir, Justin Salama, Alan Warner, Elinor Ghufoor, Khalid Sandhu, Gurpreet Al Yaghchi, Chadwan affil: Department of Otolaryngology, Imperial College Healthcare NHS Trust, London, UK sug: subj: Immunoglobulin G4-Related Disease Diagnosis Laryngeal Diseases Diagnosis Laryngeal Diseases Therapy Immunotherapy Methods Female Middle Age Adolescence Male Aged Middle Aged: 45-64 years Adolescent: 13-18 years Aged: 65+ years Female Male ab: Objective: Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognised cause of various systemic fibro-inflammatory conditions. However, laryngeal involvement as a primary feature is extremely rare. We aimed to report on a case series of such patients and examine the global literature relating to laryngeal involvement. Methods: Having previously reported a case of IgG4-RD laryngeal pseudotumour, we describe a case series of further 4 patients with primary laryngeal IgG4-RD managed by our UK quaternary airway service and provide a brief overview of laryngeal IgG4-RD. Results: Including our cases, 14 cases of primary laryngeal IgG4-RD have been reported. Vocal cord involvement is relatively uncommon. Repeat biopsies may be required to achieve histological diagnosis. Remission is achievable by commencement of immunomodulatory treatment, following which laryngeal reconstruction may be necessary. Conclusion: Laryngeal involvement is a rare presentation of IgG4-RD, itself a rare and difficult-to-diagnose condition. A high and prolonged index of suspicion is necessary from both surgical and pathological specialists for correct diagnosis and management. pubtype: Academic Journal doctype: case study pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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