Cardiac surgery outcomes in patients with antecedent kidney, liver, and pancreas transplantation: a meta-analysis.
Cardiovascular events are among the most common causes of late death in the transplant recipient (Tx) population. Moreover, major cardiac surgical procedures are more challenging and risky due to immunosuppression and the potential impact on the transplanted organ's functional capacity. We aimed to...
| Publicado en: | Reviews in Cardiovascular Medicine Vol. 21; no. 4; pp. 589 - 600 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
IMR Press
Dec2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147848949&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147848949 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15306550 1D0V jtl: Reviews in Cardiovascular Medicine issn: 15306550 maglogo: N pubinfo: dt: Dec2020 vid: 21 iid: 4 pid: 58159 pub: IMR Press artinfo: ui: 147848949 147848949 NLM33388004 147848949 10.31083/j.rcm.2020.04.192 NLM33388004 147848949 ppf: 589 ppct: 11 formats: tig: atl: Cardiac surgery outcomes in patients with antecedent kidney, liver, and pancreas transplantation: a meta-analysis. aug: au: Bacusca, Alberto Emanuel Enache, Mihail Tarus, Andrei Litcanu, Cezara Ioana Burlacu, Alexandru Tinica, Grigore affil: Department of Cardiovascular Surgery - Cardiovascular Diseases Institute, and "Grigore T. Popa" University of Medicine, 700115, Iasi, Romania sug: subj: Kidney Transplantation Adverse Effects Liver Transplantation Adverse Effects Pancreas Transplantation Adverse Effects Cardiac Surgery Adverse Effects Liver Transplantation Mortality Postoperative Complications Mortality Human Kidney Transplantation Mortality Risk Factors Cardiac Surgery Mortality Treatment Outcomes Pancreas Transplantation Mortality Risk Assessment Female Postoperative Complications Etiology Aged Time Factors Male Middle Age Comparative Studies Meta Analysis Multicenter Studies Evaluation Research Validation Studies Clinical Assessment Tools Impact of Events Scale Scales Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Cardiovascular events are among the most common causes of late death in the transplant recipient (Tx) population. Moreover, major cardiac surgical procedures are more challenging and risky due to immunosuppression and the potential impact on the transplanted organ's functional capacity. We aimed to assess open cardiac surgery safety in abdominal solid organ transplant recipients, comparing the postoperative outcomes with those of nontransplant (N-Tx) patients. Electronic databases of PubMed, EMBASE, and SCOPUS were searched. The endpoints were: overall rate of infectious complications (wound infection, septicemia, pneumonia), cardiovascular and renal events (stroke, cardiac tamponade, acute kidney failure), 30-days, 5-years, and 10-years mortality post-cardiac surgery interventions in patients with and without prior solid organ transplantation. This meta-analysis included five studies. Higher rates of wound infection (Tx vs. N-Tx: OR: 2.03, 95% CI: 1.54 to 2.67, I2 = 0%), septicemia (OR: 3.91, 95% CI: 1.40 to 10.92, I2 = 0%), cardiac tamponade (OR: 1.83, 95% CI: 1.28 to 2.62, I2 = 0%) and kidney failure (OR: 1.70, 95 %CI: 1.44 to 2.02, I2 = 89%) in transplant recipients were reported. No significant differences in pneumonia occurrence (OR: 0.95, 95% CI: 0.71 to 1.27, I2 = 0%) stroke (OR: 0.89, 95% CI: 0.54 to 1.48, I2 = 78%) and 30-day mortality (OR: 1.92, 95% CI: 0.97 to 3.80, I2 = 0%) were observed. Surprisingly, 5-years (OR: 3.74, 95% CI: 2.54 to 5.49, I2 = 0%) and 10-years mortality rates were significantly lower in the N-Tx group (OR: 3.32, 95% CI: 2.35 to 4.69, I2 = 0%). Our study reveals that open cardiac surgery in transplant recipients is associated with worse postoperative outcomes and higher long-term mortality rates. pubtype: Academic Journal doctype: meta analysis research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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