Crotoliganfuran, a new clerodane-type furano-diterpenoid from Croton oligandrus Pierre ex Hutch.
The phytochemical investigation of the methanol extract of the bark of Croton oligandrus Pierre ex Hutch yielded a new clerodane-type diterpenoid crotoliganfuran (1) along with ten other compounds including 12-epicrotocorylifuran (2), lupeol (3), syringic acid (4), aleuritolic acid acetate (5), aleu...
| Published in: | Natural Product Research Vol. 35; no. 1; pp. 63 - 72 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Published: |
Taylor & Francis Ltd
Jan2021
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147859379&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147859379 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Jan2021 vid: 35 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 147859379 10.1080/14786419.2019.1613399 147859379 ppf: 63 ppct: 9 formats: tig: atl: Crotoliganfuran, a new clerodane-type furano-diterpenoid from Croton oligandrus Pierre ex Hutch. aug: au: Yannick Stephane, Fongang Fotsing Dawe, Amadou Angelbert Fusi, Awantu Jean Jules, Bankeu Kezetas Ulrich, Kagho Kenou Donald Lateef, Mehreen Bruno, Lenta Ndjakou Ali, Muhammad Shaiq Ngouela, Silvère Augustin affil: Department of Chemistry, Higher Teachers Training College, University of Maroua, Maroua, Cameroon sug: ab: The phytochemical investigation of the methanol extract of the bark of Croton oligandrus Pierre ex Hutch yielded a new clerodane-type diterpenoid crotoliganfuran (1) along with ten other compounds including 12-epicrotocorylifuran (2), lupeol (3), syringic acid (4), aleuritolic acid acetate (5), aleuritolic acid (6), scopoletin (7), geddic acid (8), β-sitosterol (9), vanilic acid (10) and stigmastane-3,6-dione (11). Their structures were established by spectroscopic means. The extract and all the isolates were screened for their inhibitory properties against butyrylcholinesterase and urease enzymes, respectively. The extract and compounds 1, 4 and 7 displayed the most potent urease inhibitory properties with IC50 values, 22.2, 26.7 and 28.5 µM, respectively. Compound 9 was the most active of all the tested compounds against butyrylcholinesterase enzyme with an IC50 value of 36.3 µM. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|