Distribution of plasma copeptin levels and influence of obesity in children and adolescents.
In recent years, a more stable AVP surrogate, called copeptin, has been used as an adjuvant diagnostic tool for dysnatremia in adults and appears to be promising even in the pediatric age. The aim of this study is to present the distribution of plasma copeptin in a large pediatric cohort and to obse...
| Publicado en: | European Journal of Pediatrics Vol. 180; no. 1; pp. 119 - 127 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147907814&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147907814 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03406199 CR1 jtl: European Journal of Pediatrics issn: 03406199 maglogo: N pubinfo: dt: 2021 vid: 180 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 147907814 147907814 NLM32809080 10.1007/s00431-020-03777-3 NLM32809080 147907814 ppf: 119 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Distribution of plasma copeptin levels and influence of obesity in children and adolescents. aug: au: Tuli, Gerdi Munarin, Jessica Tessaris, Daniele Einaudi, Silvia Matarazzo, Patrizia de Sanctis, Luisa affil: Department of Pediatric Endocrinology, Regina Margherita Children's Hospital, Turin, Italy sug: subj: Pediatric Obesity Diagnosis Adult Adolescence Child Peptides Adult: 19-44 years Adolescent: 13-18 years Child: 6-12 years ab: In recent years, a more stable AVP surrogate, called copeptin, has been used as an adjuvant diagnostic tool for dysnatremia in adults and appears to be promising even in the pediatric age. The aim of this study is to present the distribution of plasma copeptin in a large pediatric cohort and to observe the influence of fluid consumption and obesity on its values. A cohort of 128 children and adolescents was divided into two groups on the basis of nocturnal deprivation (group A) or free access to oral fluids in the 6-8 h before blood collection (group B). At all distribution percentiles, copeptin levels were higher (p < 0.0001) in group A, as were plasma sodium levels and osmolality (p = 0.02 and p = 0.008, respectively). The influence of BMI on copeptin levels was investigated by dividing the cohort into nonobese (group C) and obese children and adolescents (group D). Copeptin levels were higher in group D (p = 0.04).Conclusion: The measurement of copeptin could represent a useful tool for the diagnostic pathway of dysnatremic conditions, but its interpretation should take into consideration the state of hydration. Furthermore, it could also be a promising marker for obesity and metabolic syndrome, although this hypothesis needs further studies to be confirmed. What is Known: • Copeptin use as a diagnostic tool in AVP-related disorders, such as diabetes insipidus or syndrome of inappropriate secretion of antidiuretic hormone, is well established in adults • In pediatric age, few studies are available, but the preliminary data, including our previous study, seems to be promising. What is New: • In this study, we represent the distribution of copeptin levels in a pediatric cohort and show the significant influence of fluid ingestion on its plasma levels. • Also BMI seems to be a significant variable on copeptin levels and may be used as an obesity marker in pediatric age. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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