Biocompatibility and osseointegration study of new prosthetic materials.
Objetive: Bone implants are increasingly used in clinical practice and, among the materials, Ti or its alloys are offer the best performance given their physicochemical properties. Alloys such as TiNbTa have been shown to improve the biomechanical characteristics of commercial pure Ti (c.p.), howeve...
| Publicado en: | Journal of Osteoporosis & Mineral Metabolism / Revista de Osteoporosis y Metabolismo Mineral (Spanish edition) Vol. 12; no. 3; pp. 92 - 98 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
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Ibanez y Plaza
Jul-Sep2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=147918514&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 147918514 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 1889836X FQ8J jtl: Journal of Osteoporosis & Mineral Metabolism / Revista de Osteoporosis y Metabolismo Mineral (Spanish edition) issn: 1889836X maglogo: N pubinfo: dt: Jul-Sep2020 vid: 12 iid: 3 pid: 84111 pub: Ibanez y Plaza artinfo: ui: 147918514 10.4321/S1889-836X2020000300004 ppf: 92 ppct: 6 formats: fmt: @attributes: type: P size: 1MB tig: atl: Biocompatibility and osseointegration study of new prosthetic materials. aug: au: M., Giner L., Santana A. F., Costa M. A., Vázquez-Gámez M., Colmenero F. J., Olmo E., Chicardi Y., Torres M. J., Montoya-García affil: Department of Normal and Pathological Cytology and Histology. Sevilla University. Sevilla (Spain) Department of Engineering and Science of Materials and Transportation. Higher Polytechnic School of Seville. Sevilla (Spain) Internal Medicine. Virgen Macarena University Hospital. Sevilla (Spain) Department of Medicine. Sevilla University. Sevilla (Spain) sug: keyword: biocompatibility cell adhesion cell culture cytotoxicity osteoblast cells TiNbTa Young's modulus ab: Objetive: Bone implants are increasingly used in clinical practice and, among the materials, Ti or its alloys are offer the best performance given their physicochemical properties. Alloys such as TiNbTa have been shown to improve the biomechanical characteristics of commercial pure Ti (c.p.), however, its osseointegration capacity needs to be evaluated. The objective of the present study was to assess the cytotoxicity and the adhesion, proliferation and differentiation capacity of osteoblastic cells in culture, influenced by discs of TiNbTa material versus Ti c.p. Material and methods: At 4 and 7 days after culture, we analyzed the MC3T3 cell line, cell viability (AlamarBlue Cell Viability Reagent. Invitrogen, Spain), as well as cell proliferation and differentiation (alkaline phosphatase activity (ALP) and scanning electron microscopy (Fixation for SEM) Student's t test was performed to determine statistically significant differences between the two groups of study discs. Results: The results obtained show very good cell viability during the study period, with no significant differences for both materials. Likewise, we detected a drop in ALP levels that was significant for both components between days 4 and 7 of the study (p <0.05). Electron microscopy images revealed good adhesion capacity to the material, as well as cell differentiation against both types of discs. Conclusions: The TiNbTa alloy as a material for bone implants offers good osseointegrative capacity, in addition to solving biomechanical problems that pure titanium presents as a component. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Journal of Osteoporosis & Mineral Metabolism / Revista de Osteoporosis y Metabolismo Mineral (Spanish edition) is the property of Ibanez y Plaza and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Journal of Osteoporosis & Mineral Metabolism / Revista de Osteoporosis y Metabolismo Mineral (Spanish edition) holder: Ibanez y Plaza dt: @attributes: year: 2020 holdings: @attributes: islocal: N |
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