Human Papilloma Virus self-sampling performance in low- and middle-income countries.
Background: Screening for HPV has led to significant reductions in cervical cancer deaths in high-income countries. However, the same results have not been achieved in low- and middle-income countries (LMICs). HPV self-sampling is a novel approach that could improve screening rates.Methods: This stu...
| Publicado en: | BMC Women's Health Vol. 21; no. 1; pp. 1 - 12 |
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| Autores principales: | , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
1/6/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147947801&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147947801 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726874 1CIP jtl: BMC Women's Health issn: 14726874 maglogo: N pubinfo: dt: 1/6/2021 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 147947801 147947801 NLM33407355 147947801 10.1186/s12905-020-01158-4 NLM33407355 147947801 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Human Papilloma Virus self-sampling performance in low- and middle-income countries. aug: au: Kamath Mulki, Ashwini Withers, Mellissa affil: Department of Family Medicine, Lehigh Valley Health Network, 1730 Chew St, 18104, Allentown, PA, USA sug: subj: Papillomavirus Infections Diagnosis Cervix Neoplasms Diagnosis Vertebrate Viruses Female Health Screening Specimen Handling Self Care Developing Countries Cervical Smears Early Detection of Cancer Papillomaviruses Human Female ab: Background: Screening for HPV has led to significant reductions in cervical cancer deaths in high-income countries. However, the same results have not been achieved in low- and middle-income countries (LMICs). HPV self-sampling is a novel approach that could improve screening rates.Methods: This study's objective is to summarize the recent literature on HPV self-sampling in LMICs, focusing on sensitivity/specificity, and feasibility/acceptability of self-sampling compared to traditional screening methods. We conducted a PubMed search for articles published in English within the last 10 years on self-sampling in LMICs.Results: Fifty eligible articles from 26 countries were included, 19 of which came from sub-Saharan Africa and 18 from Latin America/Caribbean. Seven studies examined sensitivity, with five reporting rates higher than 91%. Six reported on specificity, which was also very high at 86-97.8%. Six studies examined self-sampling concordance with provider-collected sampling, with concordance rates ranging from 87 to 97.5%. A total of 38 studies examined the feasibility/acceptability of HPV self-sampling. Participation rates were very high in all studies, even when self-sampling was done at participants' homes (over 89% participation). Overall, participants reported that HPV self-sampling was easy to perform (75-97%, 18 studies), painless (60-90%, nine studies), and preferred over provider-collected sampling (57-100%, 14 studies). Eight studies reported follow-up rates for participants who completed self-sampling; however, these rates varied widely-from 13.7 to 90%. The major benefits of self-sampling include convenience of screening from home, less embarrassment, and less travel. Improved education and awareness of self-sampling, combined with support from community health workers, could reduce perceptions of self-sampling being inferior to provider-collected sampling. Improving follow-up of abnormal results and improving linkages to treatment are also essential.Conclusion: Our literature review highlights HPV self-sampling is a well-performing test that shows promise in terms of expanding screening efforts for the prevention of cervical cancer-related deaths in LMICs. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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