Absence of significant association between UGT2B4 genetic variants and the susceptibility to anti‐tuberculosis drug‐induced liver injury in a Western Chinese population.
What is known and objective: Combination regimens of six‐month duration may increase the incidence of anti‐tuberculosis drug‐induced liver injury (ATLI), which is clinically characterized by mild cholestasis and hepatocanalicular lesions. UGT2B4 is a predominant UDP‐glucuronosyltransferase enzyme in...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 46; no. 1; pp. 66 - 74 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147968586&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147968586 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Feb2021 vid: 46 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 147968586 147968586 147968586 10.1111/jcpt.13132 147968586 ppf: 66 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Absence of significant association between UGT2B4 genetic variants and the susceptibility to anti‐tuberculosis drug‐induced liver injury in a Western Chinese population. aug: au: Chen, Hao Jiao, Lin Zhou, Juan Bai, Hao Lyu, Mengyuan Wu, Tao Wu, Lijuan Song, Jiajia Liu, Tangyuheng Yan, Hong Ying, Binwu affil: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China sug: subj: Polymorphism, Genetic Disease Susceptibility Antitubercular Agents Adverse Effects Liver Diseases Chemically Induced Liver Diseases Risk Factors Hepatotoxicity Risk Factors Risk Assessment Human China Genomics DNA Blood Genetic Profile Hospitals China Phenotype Alleles Cholestasis Chemically Induced Polymorphism, Single Nucleotide ab: What is known and objective: Combination regimens of six‐month duration may increase the incidence of anti‐tuberculosis drug‐induced liver injury (ATLI), which is clinically characterized by mild cholestasis and hepatocanalicular lesions. UGT2B4 is a predominant UDP‐glucuronosyltransferase enzyme in the human liver that plays an important role in the detoxification of bile acids, which yields water‐soluble inactive compounds that can easily be excreted in the bile or urine. This study aimed to investigate the potential association between UGT2B4 variants and the susceptibility to ATLI. Methods: Genomic DNA was extracted from whole blood sample of each patient, and all SNPs were genotyped using an improved multiplex ligation detection reaction method. Clinical symptoms and laboratory results were recorded regularly. Five genetic variants at UGT2B4(rs1131878, rs1966151, rs28361541, rs4557343 and rs79407331) were identified in a prospective study of 118 ATLI cases and 628 non‐ATLI controls. All participants were treated by first‐line anti‐TB drugs in Western China Hospital. The potential association between SNPs, ATLI risk and clinical phenotypes were determined based on the distribution of allelic frequencies and different genetic models. Results and discussion: Statistical comparisons of cases and controls after correction for multiple testing did not yield any significant association between genetic variants at UGT2B4 and risk of ATLI via the analyses of single locus and subgroup differences. What is new and conclusion: This is the first study aimed to investigate the association of UGT2B4 polymorphisms with ATLI risk. Our results revealed that UGT2B4 genetic variants are unlikely to confer susceptibility to ATLI in the Western Chinese Han population. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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