Cryptococcal fungemia and Mycobacterium haemophilum cellulitis in a patient receiving ruxolitinib: a case report and literature review.
Background: Ruxolitinib is a novel oral Janus kinase inhibitor that is used for treatment of myeloproliferative diseases. It exhibits potent anti-inflammatory and immunosuppressive effects, and may increase the risk of opportunistic infections. Here, we report a rare case of Cryptococcus neoformans...
| Publicado en: | BMC Infectious Diseases Vol. 21; no. 1; pp. 1 - 8 |
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| Autores principales: | , , |
| Formato: | case study research Journal Article |
| Publicado: |
BioMed Central
1/7/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147996243&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147996243 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712334 1CHU jtl: BMC Infectious Diseases issn: 14712334 maglogo: N pubinfo: dt: 1/7/2021 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 147996243 147996243 NLM33413168 147996243 10.1186/s12879-020-05703-2 NLM33413168 147996243 ppf: 1 ppct: 7 formats: tig: atl: Cryptococcal fungemia and Mycobacterium haemophilum cellulitis in a patient receiving ruxolitinib: a case report and literature review. aug: au: Sayabovorn, Naruemit Chongtrakool, Piriyaporn Chayakulkeeree, Methee affil: Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, 10700, Bangkok, Thailand sug: subj: Heterocyclic Compounds Adverse Effects Fungemia Microbiology Cellulitis Microbiology Cryptococcosis Microbiology Mycobacterium Infections Drug Therapy Bile Acids and Salts Therapeutic Use Antiinflammatory Agents, Non-Steroidal Adverse Effects Antiinflammatory Agents, Non-Steroidal Therapeutic Use Cryptococcosis Diagnosis Primary Myelofibrosis Drug Therapy Cryptococcus Male Opportunistic Infections Microbiology Heterocyclic Compounds Therapeutic Use Amphotericin B Therapeutic Use Opportunistic Infections Drug Therapy Antifungal Agents Therapeutic Use Coinfection Drug Therapy Mycobacterium Cellulitis Drug Therapy Human Fungemia Drug Therapy Drug Combinations Primary Myelofibrosis Complications Cryptococcosis Drug Therapy Mycobacterium Infections Microbiology Aged Antibiotics Therapeutic Use Aged: 65+ years Male ab: Background: Ruxolitinib is a novel oral Janus kinase inhibitor that is used for treatment of myeloproliferative diseases. It exhibits potent anti-inflammatory and immunosuppressive effects, and may increase the risk of opportunistic infections. Here, we report a rare case of Cryptococcus neoformans and Mycobacterium haemophilum coinfection in a myelofibrosis patient who was receiving ruxolitinib.Case Presentation: A 70-year-old Thai man who was diagnosed with JAK2V617F-mutation-positive primary myelofibrosis had been treated with ruxolitinib for 4 years. He presented with cellulitis at his left leg for 1 week. Physical examination revealed fever, dyspnea, desaturation, and sign of inflammation on the left leg and ulcers on the right foot. Blood cultures showed positive for C. neoformans. He was prescribed intravenous amphotericin B deoxycholate with a subsequent switch to liposomal amphotericin B due to the development of acute kidney injury. He developed new onset of fever after 1 month of antifungal treatment, and the lesion on his left leg had worsened. Biopsy of that skin lesion was sent for mycobacterial culture, and the result showed M. haemophilum. He was treated with levofloxacin, ethambutol, and rifampicin; however, the patient eventually developed septic shock and expired.Conclusions: This is the first case of C. neoformans and M. haemophilum coinfection in a patient receiving ruxolitinib treatment. Although uncommon, clinicians should be aware of the potential for multiple opportunistic infections that may be caused by atypical pathogens in patients receiving ruxolitinib. pubtype: Academic Journal doctype: case study research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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