Metabolite Profiling of Osteoporosis and Atherosclerosis in Postmenopausal Women: A Cross-Sectional Study.
Purpose: Atherosclerosis (AS) and osteoporosis (OP) are common causes of morbidity and mortality in postmenopausal women and are connected via an unknown mechanistic link. Metabolite profiling of blood samples may allow the identification of new biomarkers and pathways for this enigmatic association...
| Publicado en: | Vascular Health & Risk Management Vol. 16; pp. 515 - 525 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Dove Medical Press Ltd
Dec2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148043807&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148043807 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11766344 6BXM jtl: Vascular Health & Risk Management issn: 11766344 maglogo: N pubinfo: dt: Dec2020 vid: 16 pid: 45064 pub: Dove Medical Press Ltd place: Auckland, <Blank> artinfo: ui: 148043807 148043807 NLM33293818 10.2147/VHRM.S279028 NLM33293818 148043807 ppf: 515 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Metabolite Profiling of Osteoporosis and Atherosclerosis in Postmenopausal Women: A Cross-Sectional Study. aug: au: Värri, Miika Niskanen, Leo Tuomainen, Tomi-Pekka Honkanen, Risto Kröger, Heikki Tuppurainen, Marjo T sug: subj: Amino Acids Blood Postmenopause Energy Metabolism Lipids Blood Atherosclerosis Blood Biochemistry Osteoporosis Blood Case Control Studies Magnetic Resonance Spectroscopy Atherosclerosis Aged Cross Sectional Studies Female Osteoporosis Aged: 65+ years Female ab: Purpose: Atherosclerosis (AS) and osteoporosis (OP) are common causes of morbidity and mortality in postmenopausal women and are connected via an unknown mechanistic link. Metabolite profiling of blood samples may allow the identification of new biomarkers and pathways for this enigmatic association.Patients and Methods: We studied the difference in 148 metabolite levels from serum samples in postmenopausal women with AS and OP compared with those in healthy participants in this cross-sectional study. Quantitative AS was assessed by carotid artery intima-media thickness (cIMT) and carotid artery calcifications (CACs) by ultrasound, as well as OP by femoral neck (FN) bone mineral density (BMD) and 148 metabolic measures with high-throughput proton (1H) nuclear magnetic resonance (NMR) in serum samples from 280 postmenopausal (PM) women. Subjects were a randomly selected subsample from the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study. The final study population included the following groups: OP with CAC (n=16, group I), non-OP with no CAC (n=59, group II), high cIMT tertile with OP (n=11, group III) and low cIMT tertile without OP (n=48, group IV).Results: There were differences in several metabolite levels between groups I and II. The acetate level was lower in group I compared to that in group II (group I mean ± SD: 0.033 ± 0.0070; group II: 0.041 ± 0.014, CI95%: 0.018‒0.15, p=0.014). The result was similar with diacylglycerol (p=0.002), leucine (p=0.031), valine (p=0.022) and several very low-density lipoprotein (VLDL) metabolite levels, which were lower in group I compared to those in group II. However, no associations were found in adjusted analyses with total body (TB) fat mass (FM), age and statin use (p>0.05).Conclusion: Our novel study found differences in the metabolite profiling of altered amino acid and lipoprotein metabolism in participants with OP and AS compared with those in healthy women. The causative mechanisms remain unknown and further studies are needed. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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