Role of diffusion-weighted MRI and apparent diffusion coefficient value in discrimination between low versus intermediate.

Prostate carcinoma is a major health issue affecting mainly aged males; Gleason Score (GS) obtained through histopathological study gives prediction about the biological behavior of the tumor as well as the management plan and prognosis of the patient. The aim of the study to correlate the apparent...

Descripción completa

Detalles Bibliográficos
Publicado en:Archivos Venezolanos de Farmacología y Terapéutica Vol. 39; no. 7; pp. 844 - 849
Autores principales: Nee’ma Al-Waely, Noor Kathem, Al-Mosawe, Ammar Mosa J., Wadi, Zainab Kassim
Formato: Artículo
Publicado: Archivos Venezolanos de Farmacologia y Terapeutica 2020
Materias:
Acceso en línea:Ver este registro en EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=148048323&site=ehost-live
header:
  @attributes:
    shortDbName: lth
    uiTerm: 148048323
    longDbName: MedicLatina
    uiTag: AN
  controlInfo:
    bkinfo:
    jinfo:
      jid:
        07980264
        1CFT
      jtl: Archivos Venezolanos de Farmacología y Terapéutica
      issn: 07980264
      maglogo: N
    pubinfo:
      dt: 2020
      vid: 39
      iid: 7
      pid: 24188
      pub: Archivos Venezolanos de Farmacologia y Terapeutica
    artinfo:
      ui:
        148048323
        10.5281/zenodo.4424411
      ppf: 844
      ppct: 5
      formats:
        fmt:
          @attributes:
            type: P
            size: 819KB
      tig:
        atl: Role of diffusion-weighted MRI and apparent diffusion coefficient value in discrimination between low versus intermediate.
      aug:
        au:
          Nee’ma Al-Waely, Noor Kathem
          Al-Mosawe, Ammar Mosa J.
          Wadi, Zainab Kassim
        affil:
          M.B.Ch.B., F.I.B.M.S- radiology, Lecturer at College of Medicine /Al-Nahrain University, Irak.
          F.I.B.M.S- radiology, Senior radiologist at Al-Imamain Al-Kadhymain Medical City.
          F.I.B.M.S- radiology, Lecturer at College of Medicine /Al-Nahrain University.
      su:
        Diffusion magnetic resonance imaging
        Diffusion coefficients
        Prostate-specific antigen
        Prostate cancer
        Gleason grading system
        Surgical robots
      sug:
        subj:
          Diffusion magnetic resonance imaging
          Diffusion coefficients
          Prostate-specific antigen
          Prostate cancer
          Gleason grading system
          Surgical robots
      keyword:
        ADC Value
        Diffusion-Weighted MRI
        Intermediate and High Gleason Scores
        Zone Prostate Cancer
        cáncer de próstata de zona
        puntuaciones de Gleason intermedias y altas
        Resonancia magnética ponderada por difusión
        valor CDA
      ab:
        Prostate carcinoma is a major health issue affecting mainly aged males; Gleason Score (GS) obtained through histopathological study gives prediction about the biological behavior of the tumor as well as the management plan and prognosis of the patient. The aim of the study to correlate the apparent diffusion coefficient (ADC) values of prostate cancer with the Gleason score of tumor foci to assess the predictive capacity of ADC in discriminating between low grade (GS less than 7) forms higher grades (GS of 7 or more) tumor foci, aiding in the non-invasive assessment of prostate cancer aggressiveness. In this descriptive study, data of 35 patients with biopsy- proven prostate cancer localized to the peripheral zone obtained from the Urology Department including their biopsy and/or radical prostatectomy histopathological records. Subsequently, the MRI record system saved MRI Information retrospectively. The signal on the DWI image noted, corresponding ADC maps carefully examined, and ADC values of tumor foci recorded by two consultant radiologists. ADC values showed a significant negative correlation with tumor GS. ADC value of 0.75 × x 10 mm²/s was the greatest limit value to recognize cancer or prostate with 6 GS, with 93% sensitivity and specificity. Our results demonstrated that the tumor Gleason Score, and therefore, the biological aggressiveness of the tumor is likely to be inferred from the ADC values of the tumor. The present study suggests that DWI allows the noninvasive assessment of biological aggressiveness of prostate cancer, which may contribute to devising initial treatment planning strategies.
        El carcinoma de próstata es un problema de salud importante que afecta principalmente a varones de edad avanzada; el puntaje de Gleason (GS) obtenido mediante estudio histopatológico permite predecir el comportamiento biológico del tumor, así como el plan de manejo y pronóstico del paciente. El objetivo del estudio fue correlacionar los valores de coeficiente de difusion aparente (CDA) del cáncer de próstata con la puntuación de Gleason de los focos tumorales para evaluar la capacidad predictiva del CDA para discriminar entre focos tumorales de bajo grado (GS menor que 7) y grados superiores (GS de 7 o más) que ayudan en la evaluación no invasiva de la agresividad del cáncer de próstata. En este estudio descriptivo, los datos de 35 pacientes con cáncer de próstata comprobado por biopsia localizado en la zona periférica obtenidos del Servicio De Urología incluyendo sus registros histopatológicos de biopsia y/o prostatectomía radical. Posteriormente, el sistema de registro de Imagen de Resonancia Magnética (IRM) guardó la información de IRM retrospectivamente. Se anotó la señal en la imagen DWI, se examinaron cuidadosamente los mapas CDA correspondientes y los valores CDA de los focos tumorales registrados por dos radiólogos consultores. Se observó una correlación negativa significativa entre los valores de CDA y la GS tumoral. El valor CDA de 0,75 x 10 x³ mm²/s fue el mayor valor límite para reconocer el cáncer o la próstata con 6 GS, con una sensibilidad y especificidad del 93%. Nuestros resultados mostraron que la puntuación de Gleason del tumor y, por tanto, la agresividad biológica del tumor se puede inferir de los valores de CDA del tumor.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
    refInfo:
    copyright:
      @attributes:
        flag: Y
      custom: Copyright of Archivos Venezolanos de Farmacología y Terapéutica is the property of Archivos Venezolanos de Farmacologia y Terapeutica and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use.
      item: Archivos Venezolanos de Farmacología y Terapéutica
      holder: Archivos Venezolanos de Farmacologia y Terapeutica
      dt:
        @attributes:
          year: 2020
    holdings:
      @attributes:
        islocal: N