Functional recovery in human partial thickness skin wounds after application of multicomponent hydrolipidic film (MAS063DP): A prospective, open‐label, comparative clinical trial.
Acute and minor skin wounds are common in daily life. However, in clinical practice, after initial management in the acute phase, the wounds are managed mainly through observation, and the patients are usually lost to follow‐up. Considering a multicomponent hydrolipidic dressing (MAS063DP) long‐know...
| Published in: | Wound Repair & Regeneration Vol. 29; no. 1; pp. 87 - 97 |
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| Main Authors: | , , , , , , |
| Format: | clinical trial pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Jan2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148184668&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148184668 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Jan2021 vid: 29 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 148184668 146579099 148184668 148184668 10.1111/wrr.12866 148184668 ppf: 87 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Functional recovery in human partial thickness skin wounds after application of multicomponent hydrolipidic film (MAS063DP): A prospective, open‐label, comparative clinical trial. aug: au: Lin, Erh‐Ti Lin, Bor‐Shyh Tsai, Li‐Cheng Chen, Wei‐Kung Wang, Yen‐Jen Chiang, Hsiu‐Mei Chang, Chang‐Cheng affil: Department of Education, China Medical University Hospital, Taichung, Taiwan, Republic of China sug: subj: Skin Injuries Wounds and Injuries Therapy Bandages and Dressings Utilization Recovery Treatment Outcomes Human Clinical Trials Prospective Studies Comparative Studies Wound Healing Skin Physiology Questionnaires Patient Satisfaction Hydration Status Electric Impedance Descriptive Statistics ab: Acute and minor skin wounds are common in daily life. However, in clinical practice, after initial management in the acute phase, the wounds are managed mainly through observation, and the patients are usually lost to follow‐up. Considering a multicomponent hydrolipidic dressing (MAS063DP) long‐known for its safe application in eczema and recently in laser‐induced wounds, we aimed to evaluate its ability in functional recovery of impaired skin integrity during wound healing. Sixteen patients (N = 16) were enrolled and completed (n = 8 vs n = 8) this prospective, open‐label, vehicle‐controlled clinical trial with 12‐week follow‐up. Transepidermal water, skin viscoelasticity and bioimpedance analysis were measured initially, at the 1st, 4th, 8th, and 12th weeks. Improvements in these parameters were greater in the MAS063DP group (from 31.4 ± 9.0 to 16.4 ± 4.3 g/m2 h, P <.001; from 77 ± 16% to 88 ± 9%, P <.05; from 4182 ± 3823 to 2644 ± 1772 Ω) than in the white petrolatum group. No significant adverse events occurred, and all participants were more satisfied with the intervention. In this study, MAS063DP can restore skin integrity and reinstitute physiologic function as a feasible and safe intervention more markedly than management through observation during the healing process by providing protective hydrolipidic layer on the skin with simultaneous anti‐inflammatory and antioxidant activities from its key ingredients such as glycyrrhetinic acid, Vitis vinifera, telmesteine, and vitamins C and E. pubtype: Academic Journal doctype: clinical trial pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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