Anaemia and physical and mental health in the very old: An individual participant data meta-analysis of four longitudinal studies of ageing.
Objective To determine the physical and mental health of very old people (aged 80+) with anaemia. Methods Individual level meta-analysis from five cohorts of octogenarians (n = 2,392): LiLACS NZ Māori, LiLACS NZ non-Māori, Leiden 85-plus Study, Newcastle 85+ Study, and TOOTH. Mixed models of change...
| Publicado en: | Age & Ageing Vol. 50; no. 1; pp. 113 - 120 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jan2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=148188454&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 148188454 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jan2021 vid: 50 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 148188454 10.1093/ageing/afaa178 ppf: 113 ppct: 7 formats: tig: atl: Anaemia and physical and mental health in the very old: An individual participant data meta-analysis of four longitudinal studies of ageing. aug: au: Palapar, Leah Kerse, Ngaire Rolleston, Anna Elzen, Wendy P J den Gussekloo, Jacobijn Blom, Jeanet W Robinson, Louise Martin-Ruiz, Carmen Duncan, Rachel Arai, Yasumichi Takayama, Midori Teh, Ruth Consortium, for the TULIP affil: Department of General Practice and Primary Health Care , School of Population Health, The University of Auckland, New Zealand The Centre for Health , Tauranga, New Zealand Department of Clinical Chemistry and Laboratory Medicine , Leiden University Medical Center, Leiden, the Netherlands Department of Public Health and Primary Care , Leiden University Medical Center, Leiden, the Netherlands Department of Internal Medicine , Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands Population Health Sciences Institute , Newcastle University, United Kingdom Biosciences Institute , Newcastle University, United Kingdom The Newcastle upon Tyne Hospitals NHS Foundation Trust , Freeman Hospital, Newcastle upon Tyne, United Kingdom Center for Supercentenarian Medical Research , Keio University School of Medicine, Japan Faculty of Science and Technology , Keio University, Japan su: Aging Cognition Mental depression Health status indicators Life skills Mental health Activities of daily living Old age Anemia Confidence intervals Longitudinal method Meta-analysis Descriptive statistics sug: subj: Aging Cognition Mental depression Health status indicators Life skills Mental health Activities of daily living Old age Offices of Mental Health Practitioners (except Physicians) Anemia Confidence intervals Longitudinal method Meta-analysis Descriptive statistics keyword: 80 and over Aged Anaemia Cognitive function Depression 80 and over Aged Anaemia Cognitive function Depression ab: Objective To determine the physical and mental health of very old people (aged 80+) with anaemia. Methods Individual level meta-analysis from five cohorts of octogenarians (n = 2,392): LiLACS NZ Māori, LiLACS NZ non-Māori, Leiden 85-plus Study, Newcastle 85+ Study, and TOOTH. Mixed models of change in functional ability, cognitive function, depressive symptoms, and self-rated health over time were separately fitted for each cohort. We combined individual cohort estimates of differences according to the presence of anaemia at baseline, adjusting for age at entry, sex, and time elapsed. Combined estimates are presented as differences in standard deviation units (i.e. standardised mean differences–SMDs). Results The combined prevalence of anaemia was 30.2%. Throughout follow-up, participants with anaemia, on average, had: worse functional ability (SMD −0.42 of a standard deviation across cohorts; CI -0.59,-0.25); worse cognitive scores (SMD -0.27; CI -0.39,-0.15); worse depression scores (SMD -0.20; CI -0.31,-0.08); and lower ratings of their own health (SMD -0.36; CI -0.47,-0.25). Differential rates of change observed were: larger declines in functional ability for those with anaemia (SMD −0.12 over five years; CI -0.21,-0.03) and smaller mean difference in depression scores over time between those with and without anaemia (SMD 0.18 over five years; CI 0.05,0.30). Conclusion Anaemia in the very old is a common condition associated with worse functional ability, cognitive function, depressive symptoms, and self-rated health, and a more rapid decline in functional ability over time. The question remains as to whether anaemia itself contributes to worse outcomes or is simply a marker of chronic diseases and nutrient deficiencies. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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