Renal involvement in paediatric inflammatory bowel disease.

Inflammatory bowel disease (IBD), which includes Crohn's disease, ulcerative colitis and inflammatory bowel disease unclassified, is a chronic inflammatory disorder that predominantly affects the gastrointestinal (GI) tract and has a rising incidence in both children and adults. Symptoms are caused...

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Publicado en:Pediatric Nephrology Vol. 36; no. 2; pp. 279 - 286
Autor principal: Mutalib, Mohamed
Formato: exam questions review Journal Article
Publicado: Springer Nature 2021
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        atl: Renal involvement in paediatric inflammatory bowel disease.
      aug:
        au: Mutalib, Mohamed
        affil: Department of Paediatric Gastroenterology, Evelina London Children' Hospital, Westminster Bridge Road, SE1 7EH, London, UK
      sug:
        subj:
          Inflammatory Bowel Diseases Complications
          Kidney Diseases Risk Factors
          Inflammatory Bowel Diseases Drug Therapy
          Nephrotoxicity
          Child
          Renal Insufficiency
          Urolithiasis
          Glomerulonephritis
          Nephritis, Interstitial
          Amyloidosis
          Mesalamine Adverse Effects
          Azathioprine
          Purines
          Tumor Necrosis Factor Inhibitors
          Tacrolimus
          Antibodies, Monoclonal
          Child: 6-12 years
      ab: Inflammatory bowel disease (IBD), which includes Crohn's disease, ulcerative colitis and inflammatory bowel disease unclassified, is a chronic inflammatory disorder that predominantly affects the gastrointestinal (GI) tract and has a rising incidence in both children and adults. Symptoms are caused by inappropriate inflammatory response triggered by interaction between the environment, gut microbiome and host immune system in a genetically susceptible individual. Extranintestinal manifestations of IBD are common and can affect any body system outside the gut; they can precede or run parallel to GI inflammation. Renal involvement in IBD is uncommon and can be part of extraintestinal manifestation or metabolic complications of IBD. Many medications used to treat IBD can cause renal damage. Renal manifestation in children with IBD can range from asymptomatic biochemical abnormalities to variable stages of renal impairment with significant morbidity and even mortality burden.
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    language: English
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