Hyperuricemia prevalence in healthy subjects and its relationship with cardiovascular target organ damage.
Background and Aim: Heterogeneous results have been obtained in the relationship between Uric Acid (UA) and Target Organ Damage (TOD). In the present study we sought to assess the prevalence of hyperuricemia in healthy subjects as well as the role of UA in determining TOD. We evaluated vascular, car...
| Publicado en: | Nutrition, Metabolism & Cardiovascular Diseases Vol. 31; no. 1; pp. 178 - 186 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jan2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148233227&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148233227 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09394753 1F3L jtl: Nutrition, Metabolism & Cardiovascular Diseases issn: 09394753 maglogo: N pubinfo: dt: Jan2021 vid: 31 iid: 1 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 148233227 148233227 NLM32994122 148233227 10.1016/j.numecd.2020.08.015 NLM32994122 148233227 ppf: 178 ppct: 8 formats: tig: atl: Hyperuricemia prevalence in healthy subjects and its relationship with cardiovascular target organ damage. aug: au: Maloberti, Alessandro Qualliu, Esmerilda Occhi, Lucia Sun, Jinwei Grasso, Enzo Tognola, Chiara Tavecchia, Giovanni Cartella, Iside Milani, Martina Vallerio, Paola Signorini, Stefano Brambilla, Paolo Casati, Marco Bombelli, Michele Grassi, Guido Giannattasio, Cristina affil: Cardiology IV, "A. De Gasperis" Department, ASTT GOM Niguarda Ca' Granda, Milan, Italy sug: subj: Cardiovascular Diseases Epidemiology Kidney Diseases Epidemiology Hyperuricemia Epidemiology Uric Acid Blood Italy Aged, 80 and Over Kidney Diseases Blood Risk Factors Cardiovascular Diseases Blood Kidney Diseases Diagnosis Research Subjects Hyperuricemia Diagnosis Female Human Prevalence Cardiovascular Diseases Diagnosis Young Adult Adolescence Risk Assessment Cross Sectional Studies Aged Adult Middle Age Male Hyperuricemia Blood Comparative Studies Multicenter Studies Evaluation Research Validation Studies Aged, 80 & over Adolescent: 13-18 years Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background and Aim: Heterogeneous results have been obtained in the relationship between Uric Acid (UA) and Target Organ Damage (TOD). In the present study we sought to assess the prevalence of hyperuricemia in healthy subjects as well as the role of UA in determining TOD. We evaluated vascular, cardiac and renal TODs in the whole population as well as sub-grouped by gender.Methods and Results: As many as 379 blood donors participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Mass Index (LVMI) and carotid Intima-Media Thickness (IMT). Hyperuricemia was defined with the classic cut-off (>7.0 in men and >6.0 mg/dL in women) but also with a most recently defined one (5.6 mg/dL for both sex). Hyperuricemia was present in 6.3% of the whole population (7.3% males, 2.8% females) considering the classic cut-off, while, with the recently identified one, it was present in 28.2% of the whole population (37.3% males, 4.7% females). Despite all the evaluated TODs significantly correlated with UA, linear multivariate regression analysis showed that none of them, except for GFR, displayed UA as a significant covariate. Similar figures were found also when both correlation and linear regression analyses were repeated in the two genders separately.Conclusions: Hyperuricemia is an important problem also in healthy subjects and its prevalence could further increase if lower cut-off will be used. In this specific population UA is significantly associated with renal impairment while this was not the case for cardiac and vascular damage. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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