Comparison of segmentation-free and segmentation-dependent computer-aided diagnosis of breast masses on a public mammography dataset.
Purpose: To compare machine learning methods for classifying mass lesions on mammography images that use predefined image features computed over lesion segmentations to those that leverage segmentation-free representation learning on a standard, public evaluation dataset.Methods: We apply several cl...
| Publicado en: | Journal of Biomedical Informatics Vol. 113 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Academic Press Inc.
Jan2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148234646&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148234646 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15320464 OMB jtl: Journal of Biomedical Informatics issn: 15320464 maglogo: N pubinfo: dt: Jan2021 vid: 113 pid: 735 pub: Academic Press Inc. place: Burlington, Massachusetts artinfo: ui: 148234646 148234646 NLM33309994 148234646 10.1016/j.jbi.2020.103656 NLM33309994 148234646 ppct: 1 formats: tig: atl: Comparison of segmentation-free and segmentation-dependent computer-aided diagnosis of breast masses on a public mammography dataset. aug: au: Sawyer Lee, Rebecca Dunnmon, Jared A. He, Ann Tang, Siyi Ré, Christopher Rubin, Daniel L. affil: Stanford University Biomedical Informatics Training Program, United States sug: subj: Breast Neoplasms Mammography Female Early Detection of Cancer Breast Computers and Computerization Human Comparative Studies Multicenter Studies Evaluation Research Validation Studies Funding Source Female ab: Purpose: To compare machine learning methods for classifying mass lesions on mammography images that use predefined image features computed over lesion segmentations to those that leverage segmentation-free representation learning on a standard, public evaluation dataset.Methods: We apply several classification algorithms to the public Curated Breast Imaging Subset of the Digital Database for Screening Mammography (CBIS-DDSM), in which each image contains a mass lesion. Segmentation-free representation learning techniques for classifying lesions as benign or malignant include both a Bag-of-Visual-Words (BoVW) method and a Convolutional Neural Network (CNN). We compare classification performance of these techniques to that obtained using two different segmentation-dependent approaches from the literature that rely on specific combinations of end classifiers (e.g. linear discriminant analysis, neural networks) and predefined features computed over the lesion segmentation (e.g. spiculation measure, morphological characteristics, intensity metrics).Results: We report area under the receiver operating characteristic curve (AZ) values for malignancy classification on CBIS-DDSM for each technique. We find average AZ values of 0.73 for a segmentation-free BoVW method, 0.86 for a segmentation-free CNN method, 0.75 for a segmentation-dependent linear discriminant analysis of Rubber-Band Straightening Transform features, and 0.58 for a hybrid rule-based neural network classification using a small number of hand-designed features.Conclusions: We find that malignancy classification performance on the CBIS-DDSM dataset using segmentation-free BoVW features is comparable to that of the best segmentation-dependent methods we study, but also observe that a common segmentation-free CNN model substantially and significantly outperforms each of these (p < 0.05). These results reinforce recent findings suggesting that representation learning techniques such as BoVW and CNNs are advantageous for mammogram analysis because they do not require lesion segmentation, the quality and specific characteristics of which can vary substantially across datasets. We further observe that segmentation-dependent methods achieve performance levels on CBIS-DDSM inferior to those achieved on the original evaluation datasets reported in the literature. Each of these findings reinforces the need for standardization of datasets, segmentation techniques, and model implementations in performance assessments of automated classifiers for medical imaging. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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