Brainstem atrophy in the early stage of Alzheimer's disease: a voxel-based morphometry study.
Postmortem studies on patients with Alzheimer's disease (AD) have confirmed that the dorsal raphe nucleus (DRN) in the brainstem is the first brain structure affected in the earliest stage of AD. The present study examined the brainstem in the early stage of AD using magnetic resonance (MR) imaging....
| Publicado en: | Brain Imaging & Behavior Vol. 15; no. 1; pp. 49 - 60 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148318896&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148318896 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: 2021 vid: 15 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 148318896 148318896 NLM31898091 148318896 10.1007/s11682-019-00231-3 NLM31898091 148318896 ppf: 49 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Brainstem atrophy in the early stage of Alzheimer's disease: a voxel-based morphometry study. aug: au: Ji, Xiaoxi Wang, Hui Zhu, Minwei He, Yingjie Zhang, Hong Chen, Xiaoguang Gao, Wenpeng Fu, Yili affil: School of Life Science and Technology, Harbin Institute of Technology, Building 2E-417, 2 Yikuang Street, Nangang District, Harbin, Heilongjiang Province, China sug: subj: Alzheimer's Disease Alzheimer's Disease Pathology Brain Pathology Atrophy Pathology Human Magnetic Resonance Imaging Brain Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales ab: Postmortem studies on patients with Alzheimer's disease (AD) have confirmed that the dorsal raphe nucleus (DRN) in the brainstem is the first brain structure affected in the earliest stage of AD. The present study examined the brainstem in the early stage of AD using magnetic resonance (MR) imaging. T1-weighted MR images of the brains of 81 subjects were obtained from the publicly available Open Access Series of Imaging Studies (OASIS) database, including 27 normal control (NC) subjects, 27 patients with very mild AD (AD-VM) and 27 patients with mild AD (AD-M). The brainstem was interactively segmented from the MR images using ITK-SNAP. The present voxel-based morphometry (VBM) study was designed to investigate the brainstem differences between the AD-VM/AD-M groups and the NC group. The results showed bilateral loss in the pons and the left part of the midbrain in the AD-M group compared to the NC group. The AD-M group showed greater loss in the left midbrain than the AD-VM group (PFWEcorrected < 0.05). The results revealed that brainstem atrophy occurs in the early stages of AD (Clinical Dementia Rating = 0.5 and 1.0). Most of these findings were also investigated in a multicenter dataset. This is the first VBM study that provides evidence of brainstem alterations in the early stage of AD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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