Comparison between ROI-based and volumetric measurements in quantifying heterogeneity of liver stiffness using MR elastography.
Objectives: This study was conducted to quantify the heterogeneity of liver stiffness (LS) on MR elastography (MRE) by comparing ROI-based and volumetric measurements.Methods: LS was measured by ROI-based and volumetric segmentation of the liver parenchyma. Mean LS (MLS) was calculated and used to a...
| Publicado en: | European Radiology Vol. 30; no. 3; pp. 1609 - 1616 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148390801&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148390801 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: 2020 vid: 30 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 148390801 148390801 NLM31705257 148390801 10.1007/s00330-019-06478-0 NLM31705257 148390801 ppf: 1609 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparison between ROI-based and volumetric measurements in quantifying heterogeneity of liver stiffness using MR elastography. aug: au: Rezvani Habibabadi, Roya Khoshpouri, Pegah Ghadimi, Maryam Shaghaghi, Mohammadreza Ameli, Sanaz Hazhirkarzar, Bita Pandey, Pallavi Aliyari Ghasabeh, Mounes Pandey, Ankur Kamel, Ihab R. affil: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, 21287, Baltimore, MD, USA sug: subj: Liver Cirrhosis Diagnosis Magnetic Resonance Imaging Methods Ultrasonography Methods Liver Algorithms Liver Cirrhosis Physiopathology Male Aged Retrospective Design Aged, 80 and Over Middle Age Young Adult Liver Physiopathology Female Elasticity Adolescence Adult Human Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Objectives: This study was conducted to quantify the heterogeneity of liver stiffness (LS) on MR elastography (MRE) by comparing ROI-based and volumetric measurements.Methods: LS was measured by ROI-based and volumetric segmentation of the liver parenchyma. Mean LS (MLS) was calculated and used to assign stages of fibrosis. Volumetric measurements of stiffness maps were used to determine the percentage of liver volume above/below MLS and presence of LS heterogeneity. Heterogeneous stiffness was defined when the first and second most predominant stages were more than one category apart. MLS values by each method were compared using the Wilcoxon signed-rank test.Results: We included 128 patients with suspected liver fibrosis (mean age 54.4 ± 14.8 years). MLS was 2.7 ± 1.0 kPa for ROI measurements and 2.6 ± 0.9 kPa for the volumetric method (p = 0.001). Of 59 patients with normal stage (F0), 31 patients (52.5%) had > 20% of liver volume with abnormal LS (F1-F4). Heterogeneous LS was reported in 18 patients (14%).Conclusions: MLS measurement may not represent the entire spectrum of hepatic fibrosis. Volumetric segmentation may potentially improve the detection of heterogeneous fibrosis and the accuracy of LS measurement.Key Points: • Heterogeneity of hepatic fibrosis may occur in patients with chronic liver disease. • MR elastography is used to assess hepatic fibrosis by measuring liver stiffness. • Measuring liver stiffness by the ROI method and reporting a mean value may fail to detect heterogeneity of hepatic fibrosis. Volumetric assessment of liver stiffness by MR elastography may detect heterogeneity of parenchymal involvement. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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