ZTE MR-based attenuation correction in brain FDG-PET/MR: performance in patients with cognitive impairment.
Objective: One of the main challenges of integrated PET/MR is to achieve an accurate PET attenuation correction (AC), especially in brain acquisition. Here, we evaluated an AC method based on zero echo time (ZTE) MRI, comparing it with the single-atlas AC method and CT-based AC, set as reference.Met...
| Publicado en: | European Radiology Vol. 30; no. 3; pp. 1770 - 1780 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148390825&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148390825 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: 2020 vid: 30 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 148390825 148390825 NLM31748857 10.1007/s00330-019-06514-z NLM31748857 148390825 ppf: 1770 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: ZTE MR-based attenuation correction in brain FDG-PET/MR: performance in patients with cognitive impairment. aug: au: Sgard, Brian Khalifé, Maya Bouchut, Arthur Fernandez, Brice Soret, Marine Giron, Alain Zaslavsky, Clara Delso, Gaspar Habert, Marie-Odile Kas, Aurélie affil: Department of Nuclear Medicine, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, 75013, APHP, Paris, France sug: subj: Fludeoxyglucose F 18 Pharmacodynamics Brain Magnetic Resonance Imaging Methods Tomography, Emission-Computed Methods Diagnostic Imaging Methods Aged Aged, 80 and Over Middle Age Female Adult Male Impact of Events Scale Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Objective: One of the main challenges of integrated PET/MR is to achieve an accurate PET attenuation correction (AC), especially in brain acquisition. Here, we evaluated an AC method based on zero echo time (ZTE) MRI, comparing it with the single-atlas AC method and CT-based AC, set as reference.Methods: Fifty patients (70 ± 11 years old, 28 men) underwent FDG-PET/MR examination (SIGNA PET/MR 3.0 T, GE Healthcare) as part of the investigation of suspected dementia. They all had brain computed tomography (CT), 2-point LAVA-flex MRI (for atlas-based AC), and ZTE-MRI. Two AC methods were compared with CT-based AC (CTAC): one based on a single atlas, one based on ZTE segmentation. Impact on brain metabolism was evaluated using voxel and volumes of interest-based analyses. The impact of AC was also evaluated through comparisons between two subgroups of patients extracted from the whole population: 15 patients with mild cognitive impairment and normal metabolic pattern, and 22 others with metabolic pattern suggestive of Alzheimer disease, using SPM12 software.Results: ZTE-AC yielded a lower bias (3.6 ± 3.2%) than the atlas method (4.5 ± 6.1%) and lowest interindividual (4.6% versus 6.8%) and inter-regional (1.4% versus 2.6%) variabilities. Atlas-AC resulted in metabolism overestimation in cortical regions near the vertex and cerebellum underestimation. ZTE-AC yielded a moderate metabolic underestimation mainly in the occipital cortex and cerebellum. Voxel-wise comparison between the two subgroups of patients showed that significant difference clusters had a slightly smaller size but similar locations with PET images corrected with ZTE-AC compared with those corrected with CT, whereas atlas-AC images showed a notable reduction of significant voxels.Conclusion: ZTE-AC performed better than atlas-AC in detecting pathologic areas in suspected neurodegenerative dementia.Key Points: • The ZTE-based AC improved the accuracy of the metabolism quantification in PET compared with the atlas-AC method. • The overall uptake bias was 21% lower when using ZTE-based AC compared with the atlas-AC method. • ZTE-AC performed better than atlas-AC in detecting pathologic areas in suspected neurodegenerative dementia. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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