Corticospinal tract involvement in spinocerebellar ataxia type 3: a diffusion tensor imaging study.
Purpose: The aim of this study was to evaluate the integrity of the corticospinal tracts (CST) in patients with SCA3 and age- and gender-matched healthy control subjects using diffusion tensor imaging (DTI). We also looked at the clinical correlates of such diffusivity abnormalities. Methods: We ass...
| Publicado en: | Neuroradiology Vol. 63; no. 2; pp. 217 - 225 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148390906&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148390906 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: 2021 vid: 63 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 148390906 145723124 148390906 148390906 10.1007/s00234-020-02528-3 148390906 ppf: 217 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Corticospinal tract involvement in spinocerebellar ataxia type 3: a diffusion tensor imaging study. aug: au: Inada, Bruno Shigueo Yonekura Rezende, Thiago Junqueira Ribeiro Pereira, Fernando Vieira Garcia, Lucas Ávila Lessa da Rocha, Antônio José Neto, Pedro Braga Barsottini, Orlando Graziani Povoas França Jr, Marcondes Cavalcante Pedroso, José Luiz affil: Division of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil sug: subj: Cerebellar Diseases Diagnosis Spinocerebellar Ataxias Diagnosis Spinocerebellar Ataxias Radiography Magnetic Resonance Imaging Methods Human Pearson's Correlation Coefficient Retrospective Design Descriptive Statistics T-Tests Neurodegenerative Diseases Radiography Neurodegenerative Diseases Physiopathology ab: Purpose: The aim of this study was to evaluate the integrity of the corticospinal tracts (CST) in patients with SCA3 and age- and gender-matched healthy control subjects using diffusion tensor imaging (DTI). We also looked at the clinical correlates of such diffusivity abnormalities. Methods: We assessed 2 cohorts from different Brazilian centers: cohort 1 (n = 29) scanned in a 1.5 T magnet and cohort 2 (n = 91) scanned in a 3.0 T magnet. We used Pearson's coefficients to assess the correlation of CST DTI parameters and ataxia severity (expressed by SARA scores). Results: Two different results were obtained. Cohort 1 showed no significant between-group differences in DTI parameters. Cohort 2 showed significant between-group differences in the FA values in the bilateral precentral gyri (p < 0.001), bilateral superior corona radiata (p < 0.001), bilateral posterior limb of the internal capsule (p < 0.001), bilateral cerebral peduncle (p < 0.001), and bilateral basis pontis (p < 0.001). There was moderate correlation between CST diffusivity parameters and SARA scores in cohort 2 (Pearson correlation coefficient: 0.40–0.59). Conclusion: DTI particularly at 3 T is able to uncover and quantify CST damage in SCA3. Moreover, CST microstructural damage may contribute with ataxia severity in the disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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