Changes of olfactory tract in Parkinson's disease: a DTI tractography study.
Purpose: Impaired olfactory function is one of the main features of Parkinson's disease. However, how peripheral olfactory structures are involved remains unclear. Using diffusion tensor imaging fiber tracking, we investigated for MRI microstructural changes in the parkinsonian peripheral olfactory...
| Publicado en: | Neuroradiology Vol. 63; no. 2; pp. 235 - 243 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148390910&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148390910 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: 2021 vid: 63 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 148390910 148390910 148390910 10.1007/s00234-020-02551-4 148390910 ppf: 235 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Changes of olfactory tract in Parkinson's disease: a DTI tractography study. aug: au: Nigro, Pasquale Chiappiniello, Andrea Simoni, Simone Paolini Paoletti, Federico Cappelletti, Giulia Chiarini, Pietro Filidei, Marta Eusebi, Paolo Guercini, Giorgio Santangelo, Valerio Tarducci, Roberto Calabresi, Paolo Parnetti, Lucilla Tambasco, Nicola affil: Movement Disorders Center, Neurology Department, Perugia General Hospital and University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy sug: subj: Parkinson Disease Physiopathology Olfaction Disorders Magnetic Resonance Imaging Methods Scales Human Female Male Adult Middle Age Aged Aged, 80 and Over Comparative Studies Spearman's Rank Correlation Coefficient Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Purpose: Impaired olfactory function is one of the main features of Parkinson's disease. However, how peripheral olfactory structures are involved remains unclear. Using diffusion tensor imaging fiber tracking, we investigated for MRI microstructural changes in the parkinsonian peripheral olfactory system and particularly the olfactory tract, in order to seek a better understanding of the structural alternations underlying hyposmia in Parkinson's disease. Methods: All patients were assessed utilizing by the Italian Olfactory Identification Test for olfactory function and the Unified Parkinson's Disease Rating Scale-III part as well as Hoehn and Yahr rating scale for motor disability. Imaging was performed on a 3 T Clinical MR scanner. MRI data pre-processing was carried out by DTIPrep, diffusion tensor imaging reconstruction, and fiber tracking using Diffusion Toolkit and tractography analysis by TrackVis. The following parameters were used for groupwise comparison: fractional anisotropy, mean diffusivity, radial diffusivity, axial diffusivity, and tract volume. Results: Overall 23 patients with Parkinson's disease (mean age 63.6 ± 9.3 years, UPDRS-III 24.5 ± 12.3, H&Y 1.9 ± 0.5) and 18 controls (mean age 56.3 ± 13.7 years) were recruited. All patients had been diagnosed hyposmic. Diffusion tensor imaging analysis of the olfactory tract showed significant fractional anisotropy, and tract volume decreases for the Parkinson's disease group compared with controls (P < 0.05). Fractional anisotropy and age, in the control group, were significant for multiple correlations (r = − 0.36, P < 0.05, Spearman's rank correlation). Conclusions: Fiber tracking diffusion tensor imaging analysis of olfactory tract was feasible, and it could be helpful for characterizing hyposmia in Parkinson's disease. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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