Using supervised machine learning on neuropsychological data to distinguish OCD patients with and without sensory phenomena from healthy controls.
Objectives: While theoretical models link obsessive‐compulsive disorder (OCD) with executive function deficits, empirical findings from the neuropsychological literature remain mixed. These inconsistencies are likely exacerbated by the challenge of high‐dimensional data (i.e., many variables per sub...
| Published in: | British Journal of Clinical Psychology Vol. 60; no. 1; pp. 77 - 99 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Mar2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=148429386&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 148429386 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01446657 99B jtl: British Journal of Clinical Psychology issn: 01446657 maglogo: Y pubinfo: dt: Mar2021 vid: 60 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 148429386 147490776 148429386 148429386 10.1111/bjc.12272 148429386 ppf: 77 ppct: 22 formats: fmt: @attributes: type: P tig: atl: Using supervised machine learning on neuropsychological data to distinguish OCD patients with and without sensory phenomena from healthy controls. aug: au: Stamatis, Caitlin A. Batistuzzo, Marcelo C. Tanamatis, Tais Miguel, Euripedes C. Hoexter, Marcelo Q. Timpano, Kiara R. affil: Department of Psychology, University of Miami, Florida,, USA sug: subj: Neuropsychology Machine Learning Supervisors and Supervision Obsessive-Compulsive Disorder Symptoms Cognition Human Psychiatric Patients Sensory Stimulation Neuropsychological Tests Logistic Regression Algorithms Decision Making Sensation Disorders Risk Factors Sensitivity and Specificity Motivation ab: Objectives: While theoretical models link obsessive‐compulsive disorder (OCD) with executive function deficits, empirical findings from the neuropsychological literature remain mixed. These inconsistencies are likely exacerbated by the challenge of high‐dimensional data (i.e., many variables per subject), which is common across neuropsychological paradigms and necessitates analytical advances. More unique to OCD is the heterogeneity of symptom presentations, each of which may relate to distinct neuropsychological features. While researchers have traditionally attempted to account for this heterogeneity using a symptom‐based approach, an alternative involves focusing on underlying symptom motivations. Although the most studied symptom motivation involves fear of harmful events, 60–70% of patients also experience sensory phenomena, consisting of uncomfortable sensations or perceptions that drive compulsions. Sensory phenomena have received limited attention in the neuropsychological literature, despite evidence that symptoms motivated by these experiences may relate to distinct cognitive processes. Methods: Here, we used a supervised machine learning approach to characterize neuropsychological processes in OCD, accounting for sensory phenomena. Results: Compared to logistic regression and other algorithms, random forest best differentiated healthy controls (n = 59; balanced accuracy =.70), patients with sensory phenomena (n = 29; balanced accuracy =.59), and patients without sensory phenomena (n = 46; balanced accuracy =.62). Decision‐making best distinguished between groups based on sensory phenomena, and among the patient subsample, those without sensory phenomena uniquely displayed greater risk sensitivity compared to healthy controls (d =.07, p =.008). Conclusions: Results suggest that different cognitive profiles may characterize patients motivated by distinct drives. The superior performance and generalizability of the newer algorithms highlights the utility of considering multiple analytic approaches when faced with complex data. Practitioner points: Practitioners should be aware that sensory phenomena are common experiences among patients with OCD.OCD patients with sensory phenomena may be distinguished from those without based on neuropsychological processes. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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